Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)
研究概览
简要总结
To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).
详细描述
Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR [1.2]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The coronary angiography from each patient showed that lesions exist in at least one main coronary artery
排除标准
- •a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway
研究组 & 干预措施
Oxycodone group
干预措施: Oxycodone 10mg (Drug)
Sufentanil group
干预措施: Sufentanil (Drug)
结局指标
主要结局
blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)
时间窗: one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation
Under local anesthesia invasive artery line was put to the patients to monitor systolic blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)
次要结局
未报告次要终点
研究者
Yanchao Yang
Principal Investigator
Shengjing Hospital