Role of prophylactic Levetiracetam on seizure prevention in children during post CPR recovery phase -A Randomized(Double Blinded)Controlled Trial

The children between 1-month to ≤ 15 years of age, who have undergone CPR will be considered for the study. Hemodynamic stability would be achieved and patient details, course cause for cardio-pulmonary arrest will be documented. The participants will be randomized into two groups based on the computer-generated process i.e., prophylactic and the conventional group. The children in the prophylactic group will be started on antiepileptic medication which will be pre-labelled as drug X or Y and the principal investigator will be blinded from the drugused. Inj. Levetiracetam 40mg/kg/dose and followed by 20mg/kg/day in two divided doses within 30 minutes after hemodynamic stabilization and the children in the conventional group would be given equal volume of saline. The participants will be closely monitored for 7 days via EEG (electroencephalogram) and antiepileptic medication other than Levetiracetam will be initiated if they develop any clinical or non-clinical seizures as per physician discretion. The nursing staff will be taught and informed about giving drug X and drug Y in both the groups. Both the medications pre-labelled as X and Y required for study will be prepared apriori from the hospital pharmacy. If the patient doesn’t meet the inclusion criteria they would be excluded. If the child survives up to discharge, will be followed up after 30 days and 90 days.After the study is complete, the data will be recorded in Excel sheet and analysis will be performed using intention to treat process using latest SPSS version.