Computer-basierte Dosierungsregime Von Antiinfektiva Bei eingeschränkter Nierenfunktion Und Kontinuierlichen Nierenersatztherapieverfahren (Computer-based Dosage Calculation for Antibiotics in Patients With Impaired Renal Function or Renal Replacement Therapy)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- drug levels (blood)
研究概览
简要总结
Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples. In many hospitals that is still not an option. The investigators aim to show, that computer based calculation can avoid over- or under-dosing.
详细描述
Adequate dosing of antiinfective therapy in critically ill patients is most important to improve outcome. Patients with impaired or lost renal function or continuous renal replacement therapy are hard to calculate using drug information sheets or "lists" with recommendations. It is nearly impossible to avoid drug levels that are much to low or much to high without measuring the concentration in blood samples. Since that possibility is still not available in every clinic we aim to show, how a computer based calculation can help to find the adequate dosing.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients requiring antiinfective therapy
- •patients with impaired renal function or requiring continuous renal replacement therapy
排除标准
- •plasmapheresis or liver replacement therapy
- •renal replacement therapy with integrated CytoSorb®-Membrane
- •extracorporal live support
研究组 & 干预措施
Piperacillin/Tazobactam
Group of patients receiving Piperacillin/Tazobactam as antiinfective therapy
干预措施: Piperacillin/tazobactam (Drug)
Meropenem
Group of patients receiving Meropenem as antiinfective therapy
干预措施: Meropenem (Drug)
结局指标
主要结局
drug levels (blood)
时间窗: 3 days
achieved drug levels in blood samples
次要结局
- dosing changes(3 days)