Consequences of UTI on Urine pH
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Urine pH
研究概览
简要总结
Urinary tract infections (UTI) affect the urine pH and may lead to salt precipitation such as struvite. Bacteria with urease activity are known to alkalinise urine, but not much is known on how pH is changing over time during UTI.
This study aims at following urine pH progression at the time of diagnosis of UTI and during the treatment phase.
Description of the change in urine pH over time will help understanding the risk of struvite formation and potential timing of intervention.
详细描述
Adults presenting with UTI symptoms will be screened for infection and instructed to monitor urine pH during the course of treatment and 1 week after. Urine pH will be measured by the patients using calibrated pH-stix. Type of bacteria, antibiotics, and the type of diet will be monitored during the study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Symptoms of dysuria, pollakiuria, no fever AND
- •urine-stix positive for leucocytes OR positive culture (>10E5 cfu/ml)
- •Pyelonephritis
- •Inclusion Criteria:
- •Unilateral flank pain, pollakiuria, dysuria, fever (>38.5°C) AND
- •urine-stix positive for leucocytes OR positive culture (>10E5 cfu/ml)
- •Exclusion Criteria (both groups):
- •known urinary tract anatomic abnormalities
- •Presence of a urine catheter
- •Sepsis - septic shock
- •Patient taking drug interfering with urine pH (diuretics, citrate, acetazolamide, topiramate,...)
- •Patients with UTI diagnosed in the preceding month
- •Patients having received antibiotics during the preceding month
- •Male patient with a diagnosis of prostatitis
- •Presence of infected kidney cyst
- •Patient with diabetes
- •Pregnant female
- •Patient with obstructive pyelonephritis
排除标准
- 未提供
结局指标
主要结局
Urine pH
时间窗: 21 days
Urine pH is monitored by the patient every morning during the treatment phase and 7 days after the end of treatment
次要结局
未报告次要终点
研究者
Olivier Bonny
Associate professor
Centre Hospitalier Universitaire Vaudois