The Effects of Different Montages of tDCS on Muscle Strength in Healthy Adults

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: Transcranial direct current stimulation

• Registration Number: NCT04672109
• Lead Sponsor: Mahidol University

Brief Summary

To investigate the effects of different montages of tDCS on muscle strength in healthy adults

Detailed Description

Electrode montage or placement of tDCS over primary motor cortex can be categorized into unilateral (anodal or cathodal electrode over primary motor area) and bilateral tDCS (both anodal and cathodal electrode over the cortex). Previous studies reported benefits of different tDCS montages on muscle performance in healthy participants. However, there is no guideline for tDCS montages. This study aims to investigate immediate effects of different tDCS montages on muscle strength in healthy participants.

Study Timeline

• Study Start: 2020-11-16
• Study First Submitted: 2020-12-09
• Study First Submitted QC: 2020-12-16
• Study First Posted: 2020-12-17
• Primary Completion: 2022-05-31
• Study Completion: 2022-05-31
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-19
• Last Update Posted: 2022-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Healthy adults
2. Age range between 18 - 60 years old
3. Right-handed dominant identified by the Edinburg Handedness Inventory
4. No recent muscle injuries of both limbs for a past 6-months

Exclusion Criteria

1. Consumed caffeine within 24 hours prior the experiment
2. History of neurological symptoms i.e. seizures, weakness, loss of sensation or unclear history of pass illness
3. Present of metal implantation, intracranial shunt, cochlear implantation or cardiac pacemakers
4. Present of opened wound or infectious wound around scalp

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Anodal-tDCS	Transcranial direct current stimulation	Anodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the supraorbital area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
Dual-tDCS	Transcranial direct current stimulation	Dual transcranial direct current stimulation (tDCS) will be applied for 20 mins. Anode on the primary motor area (M1) of dominant hemisphere and Cathode on the primary motor area of non-dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.
Sham-tDCS	Transcranial direct current stimulation	Dual transcranial direct current stimulation (tDCS) will be applied over C3-C4 or the motor area (M1) for 20 mins. Anode on dominant hemisphere, Cathode on non-dominant hemisphere. The scope of intervention is to investigate effect of tDCS on muscle strength.
Cathodal-tDCS	Transcranial direct current stimulation	Cathodal transcranial direct current stimulation (tDCS) will be applied for 20 mins. Cathode on the primary motor area (M1) of non-dominant hemisphere and Anode on the supraorbital area of dominant hemisphere. Current intensity is fixed at 2 mA and current will flow continuously. The scope of intervention is to investigate effect of tDCS on muscle strength.

Primary Outcome Measures

Name	Time	Method
Change from baseline muscle strength after tDCS	Baseline (Pretest) and 40 minutes ( posttest)	Muscle strength will be measured in Newton by using a hand-held dynamometer.

Trial Locations

Locations (1)

Faculty of Physical Therapy, Mahidol University; 🇹🇭 Salaya, Nakhon Pathom, Thailand