The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT01844882
• Lead Sponsor: Unity Health Toronto

Brief Summary

Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality. Most dietary guidelines for CKD focus on limiting protein intake (nitrogen) and high phosphorus-containing foods. However, increasing dietary fiber has been proposed to increase fecal nitrogen excretion which may ameliorate the progress of CKD. We therefore plan to conduct a systematic review and meta-analysis on clinical trials to assess the effect of fiber on urea and creatinine as classical markers of a state of uremia in individuals with CKD. We hypothesize that increasing fiber intakes will improve urea and creatinine levels in individuals with CKD.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2013-04-29
• Study First Submitted QC: 2013-04-30
• Study First Posted: 2013-05-03
• Primary Completion: 2013-08
• Study Completion: 2013-08
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-20
• Last Update Posted: 2014-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Dietary trials in humans
• Randomized treatment allocation
• Suitable control (low fiber)
• viable endpoint data

Exclusion Criteria

• Non-human studies
• Nonrandomized treatment allocation
• Lack of a suitable control (high protein)
• no viable endpoint data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
urea	1.5 years
Creatinine	1.5 years

Secondary Outcome Measures

Name	Time	Method
Phosphorus	1.5 years