The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

• Conditions: Anterior Cruciate Ligament Injuries; Cartilage Degeneration
• Interventions: Diagnostic Test: gait testing, functional MRI

• Registration Number: NCT04968665
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Explore The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration

Detailed Description

Cartilage degeneration in the medial tibiofemoral joint is common after anterior cruciate ligament reconstruction (ACLR), which may develop into knee osteoarthritis (disability rate 21.3%). Alterations in joint biomechanical properties play an important role in cartilage degeneration after ACLR. However, the mechanism remains unclear.

Our research studied the joint kinematics and kinetics properties after ACLR and found significant changes in biomechanics in the ACLR knees. Therefore, this study will combine longitude biochemical changes in the cartilage to explore how the alterations in biomechanics would influence biochemical changes in the joint cartilage.

This study will explore the joint biomechanical properties during functional activities by motion analysis, the effects of biomechanical properties on cartilage stress distribution by finite element analysis, the long-term biochemical changes in the joint cartilage by functional MRI. This study will establish prediction models for cartilage biomechanical changes in the mid-term based on joint biomechanical properties in the early stage after ACLR, and cartilage biomechanical changes in the long-term based on joint biomechanical properties in the mid-term after ACLR. The study aims to clarify the mechanism of cartilage degeneration after ACLR and search biomechanical risk factors, in order to provide methods for clinical prevention of cartilage degeneration after ACLR.

Study Timeline

• Status Verified: 2021-07
• Study First Submitted: 2021-07-02
• Study First Submitted QC: 2021-07-08
• Last Update Submitted: 2021-07-08
• Study First Posted: 2021-07-20
• Last Update Posted: 2021-07-20
• Study Start: 2021-08-01
• Primary Completion: 2022-01-01
• Study Completion: 2024-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Unilateral ACL rupture of the knee

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Exclusion Criteria

concomitant with other ligament injury or rupture, with history of surgery or musculoskeletal system injury of the contralateral knee, and the time from injury to operation more than 8 weeks

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy volunteers	gait testing, functional MRI	gait testing and MRI at baseline for healthy volunteers
ACL-deficient patients	gait testing, functional MRI	gait testing and MRI at pre-operation, 6 months post-operation, 1 year post-operation, 2 years post-operation

Primary Outcome Measures

Name	Time	Method
knee rotation angles	At 2 years post operation.	Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping
knee extension angles	At 2 years post operation.	Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping
knee T2 value	At 2 years post operation.	knee T1 rho value by functional MRI
knee moments	At 2 years post operation.	Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping
ground reaction force	At 2 years post operation.	Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping
knee T1 rho value	At 2 years post operation.	knee T1 rho value by functional MRI