Intervention of Ovarian Cancer Based on Engineered Immune Effectors (EIEs)
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Ovarian Cancer
- Sponsor
- Shenzhen Geno-Immune Medical Institute
- Enrollment
- 20
- Locations
- 3
- Primary Endpoint
- Safety of OC-CTLs in patients using CTCAE version 4.0 standard to evaluate the level of adverse events
- Last Updated
- 6 years ago
Overview
Brief Summary
This is a single-arm, open-label, phase I/II trial to evaluate the safety and efficacy of ovarian cancer specific cytotoxic lymphocytes (OC-CTLs) in women.
Detailed Description
Ovarian cancer is a cancer that forms in or on an ovary. The majority of ovarian cancers arise from the epithelium (outer lining) of the ovary. In 2015 it was reported found in 1.2 million women and resulted in 161,100 deaths worldwide. Among women it is the seventh-most common cancer and the eighth-most common cause of death from cancer. Treatment for ovarian cancer consists of surgery, chemotherapy, immunotherapy and sometimes, radiotherapy. The kind of treatment depends on many factors, including the type of ovarian cancer, its stage and grade, as well as the general health of the patient. Adoptive immunotherapy with cytotoxic T lymphocytes (CTLs) reactive with specific viral antigens has proven to be effective. Here, the investigators aim to evaluate the safety and efficacy of multiple infusions of ovarian cancer specific cytotoxic T lymphocytes in patients.
Investigators
Lung-Ji Chang
President
Shenzhen Geno-Immune Medical Institute
Eligibility Criteria
Inclusion Criteria
- •Written, informed consent obtained prior to any study-specific procedures.
- •Age older than 10 years.
- •Eastern Cooperative Oncology Group (ECOG) PS of 0 or
- •Expected survival ≥ 12 weeks.
- •Histologically confirmed and documented high risk International Federation of Gynecology and Obstetrics (FIGO): Stage II-IV.
- •Not pregnant, and on appropriate birth control if of childbearing potential.
- •Initial hematopoietic reconstitution with
- •neutrophils (ANC) ≥ 1,000/mm\^3;
- •platelet (PLT) ≥ 100,000/mm\^
- •Proper renal and hepatic functions (ULN denotes "upper limit of normal range") with
Exclusion Criteria
- •Patients with ovarian tumors with low malignant potential (i.e. borderline tumors);
- •Patients with evidence of abdominal free air not explained by paracentesis or recent surgical procedure (prior, current or planned treatment).
- •Previous treatment of adoptive T cell therapy.
- •Current or recent treatment (within the 28-day period prior to Day 0) with another investigational drug
- •Minor surgical procedures within 2 days prior to Day 0 (including central venous access device placement for chemotherapy administration, tumor biopsies, needle aspirations).
- •Pregnant or lactating females.
- •Inadequate bone marrow function with
- •absolute neutrophil count \< 1,000/mm\^3;
- •platelet count \< 100,000/mm\^3;
- •Hb \< 9 g/dL.
Outcomes
Primary Outcomes
Safety of OC-CTLs in patients using CTCAE version 4.0 standard to evaluate the level of adverse events
Time Frame: 6 months
Physiological parameter (measuring cytokine response, fever, symptoms)
Secondary Outcomes
- Functional analyses of OC-CTLs in vitro(4 weeks)
- Anti-tumor effects(1 year)