The Early Nasojejunal Tube to Meet Energy Requirements in Intensive Care Study

Completed

• Conditions: Mechanically-ventilated, medical-surgical critically ill patients with reduced gastric motility; Other - Research that is not of generic health relevance and not applicable to specific health categories listed above

• Registration Number: ACTRN12605000149662
• Lead Sponsor: ICU Rsearch Department, The Alfred Hospital, Melbourne Victoria

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-08-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

ICU patients are eligible for enrolment if they meet all of the following: in ICU for less than 48 hours prior to enrolment, receiving invasive mechanical ventilation (through an endotracheal tube or tracheostomy, NOT a facemask) with an anticipated need for more than 48 hours of mechanical ventilation, receiving a continuous infusion of any one of morphine (>2mg/hour, fentanyl (> 20mcg/hour), or pethidine (>20mg/hour), either a single GRV > 150mls (whilst receiving EN via an NG tube, or nasogastic drainage >500mls over 12 hours (whether receiving EN or not).

Exclusion Criteria

Patients will be ineligible for enrolment if they meet any of the following criteria: previous or recent surgery which has altered the anatomy of the gastrointestinal tract (eg. oesophagectomy, gastrectomy, any gastric anastomosis surgery, gastroplasty, pyloroplasty, pancreaticoduodenectomy (Whipple's procedure), known gastric malignancy, known oesophageal varices, current admission for peptic ulceration, current mechanical bowel obstruction, current gastostomy, jejunostomy, or surgically placed enteral tube in situ, contraindication to the use of the nose and mouth for enteral tube insertion (eg recent facial trauma or surgery), receiving nutritional support prior to ICU admission, severe coagulopathy (defined by platelet count <20 and/or INR>4.0).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of EN delivered during the ICU stay.[during ICU stay]

Secondary Outcome Measures

Name	Time	Method
Amount of EN delivered.[During the first 10 days of the study.];Cumulative proportion of EN delivered.[Daily.];Ventilator associated pneumonia rate.[throughout ICU stay];Duration of mechanical ventilation.[End of mechanical ventilation];Duration of hospitalisation.[At discharge];Mortality at hospital discharge.[At discharge];Success rate of placement into both the small bowel generally and the jejunum specifically.[During study period];Complication rates (as compared to the nasogastric tube).[During study period]