Glucose Monitoring During Threatening Preterm Birth With Particular Focus on Insulin Sensitivity and Glucose Tolerance in Patients With and Without Gestational Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Blood glucose measurements
研究概览
简要总结
This study aims to show whether the hyperglycaemic phases following a treatment with glucocorticoids, as well as blood measurements correlated to high blood glucose levels and insulin resistance, vary significantly between patients with and without gestational diabetes mellitus.
详细描述
BACKGROUND:
The therapy with glucocorticoids for fetal lung maturation in the case of threatening preterm birth is an long existing part of the obstetric routine procedures. Under this therapy it should not be forgotten, that glucocorticoids can lead to a decrease of the maternal insulin sensitivity as well as they can cause an impaired maternal glucose tolerance.
Therefore a threatening preterm birth as well as the including medical therapy do challenge the glucose metabolism of mother and child.
Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, and the numbers are on the rise. GDM is characterized through an insulin resistance during the pregnancy.
High blood glucose level during pregnancy or labour can cause complications like a fetal hypoglycaemia right after birth.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •gestational age between 23+0 and 34+6
- •an oral glucose tolerance test was made and attests a healthy glucose tolerance (control group) a gestational diabetes mellitus (case group)
- •threatening preterm birth
排除标准
- •missing consent to participate
- •age under 18 years
- •age over 50 years
- •preexistent diabetes (type 1 or 2)
- •apparent disease of the thyroid gland
- •infectious diseases as HIV or Hepatitis C
- •insulin dependent gestational diabetes mellitus
结局指标
主要结局
Blood glucose measurements
时间窗: Seven days after betamethasone medication.
The patient measures their blood glucose level six times a day for seven days. The times of the measurements are before and one hour after every meal.
次要结局
- Blood Glucose Level(One week after the medication with Betamethasone for lung maturation.)
- HbA1C(One week after the medication with Betamethasone for lung maturation.)
- Insulin level(One week after the medication with Betamethasone for lung maturation.)
研究者
Lara Linsenmeier
Principal Investigator
Medical University of Vienna