Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System

Phase 3

Recruiting

• Conditions: Tyrosine Kinase Inhibitors; Chronic Myeloid Leukemia
• Interventions: Drug: treatment of TKI in CML

• Registration Number: NCT05753384
• Lead Sponsor: Poitiers University Hospital

Brief Summary

Tyrosine kinase inhibitors (TKI) have revolutionized the management and prognosis of chronic myeloid leukemia (CML). Daily treatment with TKI, which is necessary due to lack of cure, is frequently associated with moderate, chronic and sometimes severe adverse effects. The ability to permanently stop treatment with TKI has thus become a major goal in CML to prevent the occurrence of adverse events, improve quality of life and reduce the general cost of the treatment; we talk about Treatment Free Remission (TFR). It now remains to be demonstrated in a comparative prospective study that a strategy of de-escalation of the TKI treatment dose before treatment discontinuation optimizes TFR results. At the same time, it is possible to reduce adverse reactions and improve the quality of life of patients. In this context, the investigator propose to conduct a randomized clinical trial including CML patients, allowing to compare the results of TFR at 24 months between a sudden stop of treatment after a maintenance phase of dosage for 12 months and a de-escalation arm of dose (dosage reduced by 50%) for 12 months before stopping. A secondary immunological translational objective of this project will be to compare the quantitative and qualitative evolution of innate CD8 T cells between the 2 arms (abrupt cessation of ITK treatment versus progressive withdrawal) and look for a predictive innate CD8 T cells blood signature at the time of stopping treatment of a successful TFR in both arms.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-02-09
• Study First Submitted QC: 2023-02-21
• Study First Posted: 2023-03-03
• Study Start: 2023-12-01
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-26
• Last Update Posted: 2024-07-29
• Primary Completion: 2028-12-01
• Study Completion: 2029-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• Patient ≥ 18 year-old.
• Diagnosis of chronic phase CML according to WHO 2016 criteria with a typical BCR::ABL1 rearrangement (e13a2 or e14a2)
• Duration of treatment by Imatinib ≥ 4 years / ITK2G ≥ 3 years /Imatinib and ITK2G ≥ 4 years and no change of TKI or decrease in dosage in the last 6 months prior to inclusion
• Deep Molecular Response (DMR) duration ≥ 1 year
• Absence of contraindication to the continuation of the same TKI for 12 months at the same dosage according to international recommendations nd the PCR of each TKI:

Imatinib (≥ 300 mg/j) Dasatinib (≥ 50 mg/j) Nilotinib (≥ 300 mg/j) Bosutinib (≥ 200 mg/j)

• Patient not participating in another interventional study for the duration of the interventional study
• Sexually active men should use effective contraception when taking Dasatinib
• Having an health insurance
• Having signed the consent form

Non-Inclusion Criteria:

• Patients with progressive severe pathology of poor prognosis immediately compromising participation in the entire study and/or with uncontrolled chronic pathology
• ECOG ≥ 3
• Prior resistance to TKI
• Patients who have already experienced an attempt of TKI cessation
• Patients with a malignant tumour that has been treated with chemotherapy within 2 months of inclusion or undergoing chemotherapy or that will be treated with post-inclusion chemotherapy
• Protected person
• Pregnant women or women of childbearing age without appropriate contraceptive measures

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
continued treatment with TKI at 50% dose reduction	treatment of TKI in CML	continued treatment with TKI at 50% dose reduction compared to dosing received at randomization and then stopped treatment 12 months after randomization
continuation of TKI treatment without dose change	treatment of TKI in CML	continued treatment with TKI at same dose compared to dosing received at randomization and then stopped treatment 12 months after randomization

Primary Outcome Measures

Name	Time	Method
Percentage of patients in treatment free Remission (TFR) 24 months after treatment discontinuation in patients.Treatment-Free Remission (TFR) is defined as patients with Major Molecular Response (MMR) or better (BCR-ABL level ≤ 0.1% IS).	24 months after treatment discontinuation	Percentage of patients in treatment free Remission (TFR) 24 months after treatment discontinuation in patients is calculated by dividing the number of patients with no loss of MMR-Major Molecular Response (BCR-ABL level ≤ 0.1% IS) on the total number of patients.

Secondary Outcome Measures

Name	Time	Method
Difference in proportions (%) at randomization and 12 months post randomization, of innate CD8 T cells among total CD8 T cells	12 months

Trial Locations

Locations (20)

Chu Angers; 🇫🇷 Angers, France

Ch Annecy; 🇫🇷 Annecy, France

Ch Bayonne; 🇫🇷 Bayonne, France

Chu Brest; 🇫🇷 Brest, France

CH Brive la Gaillarde; 🇫🇷 Brive-la-Gaillarde, France

Ch Chambery; 🇫🇷 Chambéry, France

Ch La Rochelle; 🇫🇷 La Rochelle, France

CHI Creteil; 🇫🇷 Créteil, France

CHU Limoges; 🇫🇷 Limoges, France

Chu Lille; 🇫🇷 Lille, France

Centre Léon Bérard; 🇫🇷 Lyon, France

Ch Perigueux; 🇫🇷 Périgueux, France

Ch Mont de Marsan; 🇫🇷 Mont-de-Marsan, France

Chu Nancy; 🇫🇷 Nancy, France

Chu Nantes; 🇫🇷 Nantes, France

Chu Poitiers; 🇫🇷 Poitiers, France

Hopital Prive Du Confluent; 🇫🇷 Nantes, France

Chu Tours; 🇫🇷 Tours, France

Oncopole Toulouse; 🇫🇷 Toulouse, France

CH Versailles; 🇫🇷 Versailles, France