Effect of Prolonged GnRh Agonist Therapy on the Outcome of In-Vitro Fertilization& Embryo Transfer in Endometrioma Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Number of patients with urine pregnancy test positive 2 weeks after embryo transfer
研究概览
简要总结
Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm &with or without GnRh agonists for all endometrioma patients
详细描述
Group 1 consists of 30 patients of endometrioma more than 5cm subdivided into:
Group 1A;Cyst aspiration followed by standard long protocol in 15 patients Group 1B;Cyst aspiration followed by GnRh suppression for 3 months then standard long protocol in 15 patients
Group 2 consists of 30 patients of endometrioma less than 5cm subdivided into :
Group 2A;no intervention to the cyst. Standard long protocol Group 2B;GnRh suppression for 3 months then standard long protocol
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •endometrioma patients
排除标准
- •Follicle stimulating hormone(FSH)10 or more
- •hydrosalpinx
- •GnRh suppression in the last 12 months
研究组 & 干预措施
1A endometrioma more than 5cm
Endometrioma aspiration GnRh agonist :Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI
干预措施: endometrioma aspiration (Procedure)
1A endometrioma more than 5cm
Endometrioma aspiration GnRh agonist :Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI
干预措施: GnRh agonist ( Decapeptyl ) (Drug)
1A endometrioma more than 5cm
Endometrioma aspiration GnRh agonist :Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI
干预措施: standard long stimulation protocol (Procedure)
1B endometrioma more than 5cm control
Endometrioma aspiration Standard long stimulation protocol & ICSI
干预措施: endometrioma aspiration (Procedure)
1B endometrioma more than 5cm control
Endometrioma aspiration Standard long stimulation protocol & ICSI
干预措施: standard long stimulation protocol (Procedure)
2A endometrioma less than 5cm
Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI
干预措施: GnRh agonist ( Decapeptyl ) (Drug)
2A endometrioma less than 5cm
Decapeptyl 3.75mg intramuscular Standard long stimulation protocol & ICSI
干预措施: standard long stimulation protocol (Procedure)
2B endometrioma less than 5cm control
Standard long stimulation protocol & ICSI
干预措施: standard long stimulation protocol (Procedure)
结局指标
主要结局
Number of patients with urine pregnancy test positive 2 weeks after embryo transfer
时间窗: 5 months
次要结局
未报告次要终点
研究者
suzy abdelaziz Abdelhamid
lecturer of obgyn.
Kasr El Aini Hospital