Evaluation Study of a Delirium Prevention Policy Using Prophylactic Haloperidol in Critically Ill Patients With a High Risk for Delirium
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Delirium
- Sponsor
- Radboud University Medical Center
- Enrollment
- 650
- Locations
- 1
- Primary Endpoint
- Delirium incidence
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
Haloperidol is prescribed in high risk ICU patients concerning delirium (50% or more chance to develop delirium detected with the delirium prediction model PRE-DELIRIC, or patients with history of dementia or alcohol abuse)since the delirium protocol is changed and haloperidol is added as a prevention treatment we are gathering information what the effect is on several aspects of delirium
Detailed Description
Measurement the effect of haloperidol as delirium preventive intervention. Determining effect on: - delirium incidence in the ICU - different subtypes of delirium - delirium free days in 28 days - days on the ventilator - length of stay on the ICU and In-Hospital - 28-day mortality - incidence of unexpected removal of tubes, and effect between different groups of patients. Safety of haloperidol concerning QT-time, extrapyramidal symptoms. Data are compared with the data of a historical cohort
Investigators
Mark van den Boogaard
PhD
Radboud University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Patients With Predicted Delirium Chance of \>50% or history of dementia or alcohol abuse and treated with haloperidol
Exclusion Criteria
- •CAM-ICU is Not Applicable
- •Patients Admitted 24hours or Shorter on the ICU, Patients Who Are Delirious Within 24 Hours After ICU Admission
- •patients whereby haloperidol is contra-indicated
Outcomes
Primary Outcomes
Delirium incidence
Time Frame: one year
Delirium is diagnosed as minimal one positive CAM-ICU screening during complete ICU admission. Incidence rate is compared with historical cohort data
Secondary Outcomes
- duration of delirium days on mechanical ventilator Length of stay in the ICU and in-hospital in-hospital mortality incidence of unplanned removal of tube incidence of delirium subtypes(one year)
- Effect haloperidol on biomarkers(one year)