The Impact of Passive Heat Treatment on Glycaemic Response During an Oral Glucose Tolerance Test in Diabetic Patients
- Conditions
- Diabetes Mellitus, Type 2
- Interventions
- Device: Sham saunaDevice: Infrared sauna heating
- Registration Number
- NCT05610046
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Type 2 diabetes mellitus (T2DM) is a metabolic disease with a rapidly increasing incidence world-wide. The disease is characterizedby a decreased glucose tolerance as a result of insulin resistance, resulting in poor blood glycaemic control. Blood glucose loweringmedications are widely available, but their effect stagnates as T2DM progresses. New treatment regimens are required to combatthe disease. Although therapies such as physical exercise have been shown to induce beneficial effects on glycaemic control inT2DM patients, not all patients are able to perform exercise. Passive heating treatment (PHT) might be an alternative strategy toreduce insulin resistance, as it has been postulated to have comparable effects on the cardiovascular system as exercise. PHT hasbeen linked to numerous health benefits, including improved cardiovascular- and pulmonary function, pain alleviation and metabolichealth. In addition, long term use of PHT shows promising effects on glycaemic control in T2DM patients. However, the acute effectsof PHT on glucoregulation are yet to be determined. Therefore, in this study we will assess the acute impact of passive heat treatment on the post-prandial glycaemic response during an OGTT in T2DM patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 12
- Aged ≥50 years old
- Body mass index 18.5 - 35 kg/m2
- DM type 2
- Using oral blood glucose lowering medication
- Able to give informed consent
- Insulin dependence
- Changes in diabetes medication in the past 3 months
- Allergy for one of the food items used
- >5% weight change in the previous 6 months
- Participating in a structured (progressive) exercise program, or in the past 3 months.
- Frequent (once per week or more) user of infrared (or traditional) sauna in the past 3 months
- Inability to tolerate sauna/high temperatures
- Smoking
- Diagnosed with cardiovascular disease (e.g. unstable angina pectoris or recent myocardial infarction), kidney failure (eGFR < 60 ml/min/1.73m2), rheumatoid arthritis
- Diagnosed musculoskeletal, GI tract, metabolic (except diabetes) or pulmonary (e.g. COPD) disorders that are expected to influence study outcomes
- Having a pacemaker, defibrillator, or any other type of metal implant
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Non-heated sauna session Sham sauna The test days will consist of sitting in an infrared sauna cabin (HM-LSE-3 Professional edition, Health Mate, Belgium). Participants will sit in an infrared sauna at 21° Celsius for a total of 40 minutes. Heated sauna session Infrared sauna heating The test days will consist of sitting in an infrared sauna cabin (HM-LSE-3 Professional edition, Health Mate, Belgium). Participants will sit in an infrared sauna at 60° Celsius (humidity not controlled in an infrared sauna) for a total of 40 minutes.
- Primary Outcome Measures
Name Time Method Glycaemic response (Matsuda index) 120 minutes OGTT
- Secondary Outcome Measures
Name Time Method Gutt insulin sensitivity index 120 minutes from OGTT values
HOMA-IR Baseline fasting glucose and insulin values
Plasma volume/hematocrit Throughout test day (3h)
Trial Locations
- Locations (1)
Maastricht University Medical Centre +
🇳🇱Maastricht, Netherlands