A study where patients undergoing surgeries of liver and gallbladder will be exposed to different gases of anesthetic agents during the operatio
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/05/067116
- Lead Sponsor
- Office of the Principal, Midnapore medical college
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. All patients undergoing elective non-malignant hepatobiliary surgeries
2. ASA I, II patients
Exclusion Criteria
Severe ischemic heart disease, coagulopathy, chronic obstructive pulmonary disease, neuromuscular disorders
Pregnant and lactating mothers
Body mass index more than 30kg/m2
Allergy to drugs used in study or history of malignant hyperthermia in the family
Any event other than switching inhalational drugs which cause their stoppage during study
Surgery duration less than 90minutes or more than 3 hours
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recovery profile after recovery from general anaesthesia based on CAM score (Confusion assessment score) where 0-2 means no delirium, 3-5 means mild to moderate delirium and 6-7 means severe delirium <br/ ><br> <br/ ><br>Timepoint: Outcome will be assessed at: After surgery at extubation, 1,2,4,6,8,10,15,20,25,30,45,60,75,90 and 120 minutes post extubation
- Secondary Outcome Measures
Name Time Method Monitoring hemodynamic parameters and recovery parameters in the intraoperative and post-operative period like mean arterial pressure, heart rate, SpO2, respiratory rate, tidal volume, MAC, PEEP and ETCO2 in the intra operative period and Mean arterial pressure, heart rate, SPO2, Respiratory rate, VAS score and Ramsay sedation score, GCS and Post operative nausea and vomiting in the post operative periodTimepoint: 1. Intraoperative time points are: 0,3,6,9,12,15,18,21,24, 27,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180 minutes <br/ ><br> <br/ ><br>2. Post operative time points are: <br/ ><br>1,2,4,8,12,24 hours