The neural basis and treatment of reading disability in children with neurofibromatosis type 1

Not Applicable

Completed

• Conditions: eurofibromatosis type 1; Reading difficulties; Neurofibromatosis type 1; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders; Neurological - Other neurological disorders

• Registration Number: ACTRN12611000779976
• Lead Sponsor: The Children's Hospital at Westmead

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-07-26
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. All participants must fulfil the diagnosis of NF1 based on NIH criteria
2. Participants must have a full scale IQ greater than or equal to 80 (WISC-IV) or if a significant discrepancy is present between PRI and VCI the higher will be used. This index used must be 80 or above
3. Participants must have access to a computer and the internet

Exclusion Criteria

1. Intracranial pathology such as epilepsy, hydrocephalus, diagnosed traumatic brain injury, or progressive intracranial tumours (children with asymptomatic or static lesions will be eligible);
2. Significant visual and/or hearing problems;
3. Currently taking psychotropic medication
4. Evidence/history of severe psychological disturbance
5. Insufficient English to complete the assessments

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Castles and Coltheart 2 Nonword Reading Test[At Time 1, Time 2 (after 8 weeks of no treatment; baseline control), Time 3 (after 8 weeks of training) , and at Time 4 (8 weeks after completing training).];Castles and Coltheart 2 Irregular Word Reading Test[At Time 1, Time 2 (after 8 weeks of no treatment; baseline control), Time 3 (after 8 weeks of training) , and at Time 4 (8 weeks after completing training).]

Secondary Outcome Measures

Name	Time	Method
Test of Word Reading Efficiency (TOWRE) Sight Word Efficiency and Phonetic Decoding Efficiency[At Time 1, Time 2 (after 8 weeks of no treatment; baseline control), Time 3 (after 8 weeks of training) , and at Time 4 (8 weeks after completing training).];Phonological recoding subskills (letter identification, parsing, letter-sound conversion, blending)[At Time 1, Time 2 (after 8 weeks of no treatment; baseline control), Time 3 (after 8 weeks of training) , and at Time 4 (8 weeks after completing training).];The Test of Everyday Reading Comprehension[At Time 1, Time 2 (after 8 weeks of no treatment; baseline control), Time 3 (after 8 weeks of training) , and at Time 4 (8 weeks after completing training).];The Kohnen Spelling Test for Nonwords and the Kohnen Spelling Test for Irregular Words[At Time 1, Time 2 (after 8 weeks of no treatment; baseline control), Time 3 (after 8 weeks of training) , and at Time 4 (8 weeks after completing training).]