Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome (POTS)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- RH-PAT index
研究概览
简要总结
The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS. This study will test whether the blood vessels of people with POTS will react differently to certain tests than people without POTS.
The hypothesis of the study is:
Patients with POTS will have vascular endothelial dysfunction compared with control subjects.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages between 18-60 years old
- •Male and female subjects are eligible
- •Able and willing to give informed consent
- •Additional criteria for POTS:
- •Diagnosed with postural tachycardia syndrome by the Vanderbilt Autonomic - Dysfunction Center (
- •increase in heart rate >/= 30 beats/minute with position change from supine to standing for 10 minutes and/or
- •Chronic symptoms consistent with POTS that are worse when upright and get better with recumbence.
- •Additional criteria for Control subjects:
- •Healthy, non-obese, non-smokers without orthostatic tachycardia
- •Selected to match profiles of POTS patients (gender, age)
- •Not using vasoactive medications
排除标准
- •Overt cause for postural tachycardia (such as acute dehydration)
- •Inability to give, or withdraw informed consent
- •Pregnancy
- •Other factors in the investigator's opinion would prevent the subject from completing the study
结局指标
主要结局
RH-PAT index
时间窗: The study will be complete in approximately 2 hours. There is no follow-up to this study.
The primary analysis of RH-PAT will involve a non-parametric, Mann Whitney U test of RH-PAT between POTS patients and Control subjects.
次要结局
未报告次要终点
研究者
Alfredo Gamboa
Research Assistant Professor of Medicine
Vanderbilt University Medical Center