The Role of Incretins in Bone Remodeling in Humans
- Conditions
- IncretinsOsteoporosisHealthyBone Remodeling
- Registration Number
- NCT03966261
- Lead Sponsor
- University Hospital, Angers
- Brief Summary
The role of incretins (GIP and GLP-1) on cells and bone tissue has been shown in cellular and animal studies. In humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is unknown. The serum incretin concentration is low and increases rapidly after a meal. This increase is brief, incretins being rapidly degraded by dipeptidylpeptidase 4 (DPP-4). The dosage of these hormones is complex and the basal "normal" serum concentrations and after feeding in healthy subjects are unknown. Before any study on the effect of incretins on bone remodeling in humans, it is necessary to establish physiological concentrations of incretins in healthy subjects.
The aim of this study is to estimate physiological concentrations of incretins in healthy subject.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 104
- healthy women and men
- known osteoporosis
- osteoporotic fracture
- tobacco
- alcohol : > 2 glasses/day
- type 1 and type 2 diabetes
- BMI < 19kg/m² or > 30kg/m²
- heart failure, kidney failure
- cancer
- bariatric surgery
- graft
- cirrhosis
- use in the past year : bisphosphonate, denosumab, raloxifene, teriparatide, oral or IV glucocorticoid during 3 months or more
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method incretins concentrations before and after a meal in healthy subjects 2 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Angers
🇫🇷Angers, France