Association Between Light Spectrum and Survival After Cataract Surgery

Completed

• Conditions: Age-related Cataract; Glaucoma; Circadian Rhythm Disorders; Age Related Macular Degeneration; Cataract
• Interventions: Device: Blue-light filtering intraocular lens; Device: Conventional intraocular lens

• Registration Number: NCT04187157
• Lead Sponsor: University of Pittsburgh

Brief Summary

This study was a retrospective observational cohort analysis of subjects aged 65 years and older, who underwent bilateral cataract surgery within a single (15 hospital) healthcare system, to determine the association between type (conventional or blue-light filtering) of implanted intraocular lens and survival.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2019-04-30
• Study Completion: 2019-04-30
• Study First Submitted: 2019-11-26
• Status Verified: 2019-12
• Study First Submitted QC: 2019-12-03
• Last Update Submitted: 2019-12-03
• Study First Posted: 2019-12-05
• Last Update Posted: 2019-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10192

Inclusion Criteria

• The study population consisted of all adult patients (at least 65 years) who underwent bilateral cataract surgery between January 01, 2012 and January 01, 2018 within the University of Pittsburgh Medical Center (UPMC) healthcare system. To be considered bilateral and concomitant, cataract surgery had to be performed on both the left and the right eye within a 365-day period.

Exclusion Criteria

• We excluded patients undergoing unilateral cataract surgery, surgery to replace or repair a previously implanted IOL, or bilateral implantation with one Blue-IOL and one Natural-IOL (i.e., mixed IOL transmission properties).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Blue-light filtering intraocular lens (IOL)	Blue-light filtering intraocular lens	Bilateral implantation of blue-filtering intraocular lens. Blue-IOL, in addition to ultraviolet, also impede the transmission of the lower visible blue spectrum between 400 and 500nm.
Conventional intraocular lens (IOL)	Conventional intraocular lens	Bilateral implantation of conventional ultraviolet light-blocking intraocular lens

Primary Outcome Measures

Name	Time	Method
All-cause mortality	From the date of the initial cataract surgery until the date of death or end of the study period (April 30, 2019), whichever occurred first, assessed up to 2,310 days.	The primary outcome was all-cause mortality. Mortality was identified based on the Social Security Death Master File and discharge status. Follow-up started from the day after the initial surgery until the end of the study period or death, whichever occurred first. Time to death was calculated as the number of days from the first cataract surgery to death. Participants who did not have a recorded death were censored on April 30, 2019.

Trial Locations

Locations (1)

UPMC-Presbyterian Hospital; 🇺🇸 Pittsburgh, Pennsylvania, United States