Measuring hepatic steatosis with ultrasound and MRS in children with overweight or obesity

Recruiting

• Conditions: Obesitas; fatty liver disease; Non-alcoholic fatty liver disease; 10019654

• Registration Number: NL-OMON54724
• Lead Sponsor: Kindergeneeskunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 54

Inclusion Criteria

· Participation in the COACH program
· Aged below 18 years

Exclusion Criteria

· Steatosis on liver ultrasonography
· Elevated liver transaminase levels above two times the upper limit of normal
(>44 U/L for girls and > 52 U/L for boys)
· Implanted medical devices such as pacemakers or neurostimulators
· Metal objects in the body (for instances prosthetics, piercings, metal parts
in the eye, permanent eyeliner)
· Previous brain surgery
· Cardiac arrhythmia
· Epilepsy
· Claustrofobia
· Not wanting to be informed about accidental findings on MRS

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Ultrasonographic hepato-renal index and liver fat percentage as determined by<br /><br>magnetic resonance spectroscopy.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Metabolic and anthropometric parameters, to correlate with the measured liver<br /><br>parameters (for example waist-circumference, lipids, blood pressure and glucose<br /><br>metabolism). The goal is to gain more insight into which children can be<br /><br>identified as being at-risk for developing NAFLD based on their cardiometbolic<br /><br>profile. </p><br>