Microwave Ablation in Ground Glass Nodules
- Conditions
- Microwave AblationLung Cancer
- Interventions
- Other: Microwave ablaton
- Registration Number
- NCT03490890
- Lead Sponsor
- Shandong Provincial Hospital
- Brief Summary
GGO was commonly observed recently.Radiofrequency ablation has been widely applied in the treatment of patients with GGO. No study had explored the microwave ablation in the treatment of GGO.
- Detailed Description
GGO was common with the development of image. Treatments of GGO include radical surgery and irradiation. For patients who were poor candidate of surgery, image guided thermal ablation could be an alternative.Radiofrequency ablation has been widely applied in the treatment of eary-stage non small cell lung cancer and those patients with GGO. However, up to date, no study had explored the microwave ablation in the treatment of GGO.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Patient has a histologically verified AIS or MIA.
- The tumors small enough to treat (usually β€3 cm), and without chest pleura invasion.
- Solid cements in the GGO less than 50%.
- No other sites of disease observed.
- Patient is not a candidate for surgical removal of the cancer, or refused surgery.
- Patient is not a candidate for radiation therapy, or refused radiation therapy.
- Patient has > 6 month life expectancy.
- Eastern Cooperative Oncology Group performance status of 0 to 2.
- No prior anticancer treatments including surgery, radiation,chemotherapy or local treatments.
- Sufficient organ functions.
- Written informed consent.
- Active bacterial or fungous infection.
- Simultaneous or metachronous (within the past 5 years) double cancers.
- Women during pregnancy or breast-feeding.
- Interstitial pneumonitis, pulmonary fibrosis, or severe pulmonary emphysema.
- Uncontrollable diabetes mellitus. History of severe heart disease, heart failure, myocardial infarction within the past 6 months or attack of angina pectoris within the past 6 months.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Microwave ablation in the GGO Microwave ablaton Patients with GGO were treated with microwave ablation.
- Primary Outcome Measures
Name Time Method The survival of patients with GGO treated with MWA From the date of randomization until the date of the date of death from any cause, assessed up to 60 months The overall survival
- Secondary Outcome Measures
Name Time Method The disease free survival of patients with GGO treated with MWA From date of randomization until the date of first documented progression, assessed up to 60 months The disease free survival
Trial Locations
- Locations (15)
Liaocheng Cancer Hospital
π¨π³Liaocheng, Shandong, China
Affliated Hospital of Taishan Medical University
π¨π³Taian, Shandong, China
Yantai Yuhuangding Hospital
π¨π³Yantai, Shandong, China
Tengzhou center of people's hospital
π¨π³Zaozhuang, Shandong, China
The People's Hospital of Pingyi Country
π¨π³Linyi, Shandong, China
The People's Liberation Army 88 Hospital
π¨π³Taian, Shandong, China
Weifang People's Hospital
π¨π³Weifang, Shandong, China
Affliated Hospital of Shandong Academy of Medical Sciences
π¨π³Jinan, Shandong, China
Shandong Provincial Hospital
π¨π³Jinan, Shandong, China
Affliated Hospital of Jining Medical University
π¨π³Jining, Shandong, China
Binzhou Medical University Hospital
π¨π³Binzhou, Shandong, China
Dezhou People's Hospital
π¨π³Dezhou, Shandong, China
The Second People's Hospital of Dezhou
π¨π³Dezhou, Shandong, China
Jinan Military General Hospital
π¨π³Jinan, Shandong, China
Shandong Provincial Hospital affliated to Shandong University
π¨π³Jinan, Shandong, China