Comparative study of the effects of different intra-operative end-tidal CO2 levels on intra and post-operative anesthesia complication in adult patients under general anesthesia for PCNL.
- Conditions
- A descriptive study has shown relative safety and benefits of higher CO2 levels and mild hypercapnia. Effects of different levels of end-tidal CO2 concentration have not been evaluated in a controlled trial.
- Registration Number
- JPRN-UMIN000009161
- Lead Sponsor
- Department of Anesthesia, Isfahan University of Medical Sciences
- Brief Summary
Results: Seventy-five patients completed the study (52 male and 23 female). Ten (38.5%), four (16%) and two (8.3%) patients developed post-operative vomiting in the hypocapnia, normocapnia and hypercapnia groups, respectively (P = 0.025). The nausea score was significantly lower in the hypercapnic group compared with the other groups (3.9 +- 1.8, 3.2 +- 2.1 and 1.3 +1 1.8 in the hypocapnia, normocapnia and hypercapnia groups, respectively; P = 0.000). Time to return of spontaneous respiration and awakening were significantly decreased in the hypercapnia group compared with the other groups (P < 0.01). Conclusion: Mild intra-operative hypercapnia has a protecting effect against the development of post-operative nausea and vomiting and decreases the duration of emergence and recovery from general anesthesia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 78
Not provided
Addiction Smoker History of cardiorespiratory Elevated BUN or creatinine BMI > 30 History of PONV Recent anesthesia with volatiles
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rates of cardio-respiratory complications
- Secondary Outcome Measures
Name Time Method Mean time to full recovery Mean recovery room stay duration Postoperative rates of shiverng, restlessness, nausea and vomiting