Role of PET/CT scan to look for response of chemo and radiotherapy in esophageal cancer before surgeryPurpose of this study is to see whether PET/CT scan is useful to assess whether chemo and radiotherapy are working and the cancer is reducing or not
- Conditions
- Health Condition 1: null- Carcinoma esophagus patients undergoing neoadjuvant chemoradiotherapy
- Registration Number
- CTRI/2014/01/004276
- Lead Sponsor
- All India Institute of Medical Sciences New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 50
1.Age < 65 years
2.Squamous cell carcinoma
3.Good performance status (Eastern Cooperative Oncology Group [ECOG] grades 0, 1 and 2)
4. Contrast enhanced computerized tomographic (CECT) scan suggesting a potentially resectable lesion. The features of resectability assessed on CECT scan will include - no evidence of infiltration of mediastinal structures such as the aorta (angle of contact <90°, no obliteration of the triangular fat space between the esophagus, aorta, and spine), and pericardium, and no evidence of tracheobronchial fistula or tumor extension into the airway lumen.
5.No evidence of distant metastasis on CECT.
1.Comorbid conditions which would preclude esophagectomy
Poor performance status (ECOG > 2)
American Society of Anesthesiologists class IV
2.Metastatic disease detected on evaluation
3.Involvement of mediastinal structures
4.Carcinoma involving cervical esophagus
5.Previous radiotherapy or chemotherapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the accuracy of 18 F-FDG PET in the prediction of tumor response to neoadjuvant therapy in patients with esophageal and gastroesophageal junction cancers.Timepoint: PET/CT before and after neoadjuvant chemoradiotherapy and results are compared to Histopatholgy
- Secondary Outcome Measures
Name Time Method comparing metabolic response between Ct and PET/CTTimepoint: 2 years