Incidence and Risk Factors of Urosepsis in Patients With Urinary Tract Calculi Receiving Surgical Intervention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 865
- 试验地点
- 1
- 主要终点
- Rate of urosepsis diagnosis
研究概览
简要总结
Urosepsis is one of major cause of the overall sepsis leading to high morbidity and mortality, which commonly resulted from urinary tract calculi. The investigator aim to identified the incidence and risk factors of urosepsis in the patients with urinary tract calculi underwent surgical intervention in tertiary-care university hospital.
详细描述
Sepsis is one of the leading cause of death of hospitalized patients in Thailand. Urosepsis or sepsis which originate from urinary tract infection was reported around 9-31% of the overall sepsis syndrome. Urinary tract calculi requiring surgical procedure was reported as a common cause of urinary tract infection. Therefore, the investigators aimed to identified the incidence and risk factors of urosepsis in the patients with urinary tract calculi underwent surgical intervention in tertiary-care university hospital.
Moreover, the patients with sepsis syndrome will be suffered from many complications such as acute respiratory distress syndrome, acute kidney injury, etc. Currently, there were many early waring scores to predict the risk of complications to help promptly treatment and decrease the severity. The investigator would like to compare the systemic inflammatory response syndrome (SIRS) criteria,Modified Early Warning Score (MEWS) and Quick Sequential Organ Failure Assessment (qSOFA) score to the prediction of postoperative complications in this group of patients.
The last primary objective of this study is to follow the course of the patients diagnosed as urosepsis if they had been treated properly according to the sepsis bundle guideline and their outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with urinary tract calculi requiring surgical procedure
排除标准
- •Incomplete data
结局指标
主要结局
Rate of urosepsis diagnosis
时间窗: 7 days after surgery
According to urine exam and SIRS criteria of sepsis
Date of urosepsis diagnosis
时间窗: 7 days after surgery
date of diagnosis of urosepsis
Mortality rate
时间窗: 30 days after surgery
Number of deceased patient after surgery
次要结局
- Rate of intensive care unit admission(7 days after surgery)
- Length of stay(7 days after surgery)
- Rate of mechanical ventilation requirement(7 days after surgery)
- Rate of renal replacement therapy requirement(30 days after surgery)
- Prevalence of acute kidney injury(30 days after surgery)
- Rate of blood transfusion(7 days after surgery)
- Rate of re-operation(7 days after surgery)
研究者
Aphichat Suphathamwit,
Assistant Professor
Mahidol University