A Retrospective Study of the Effects of Different Parameters on Motor Symptoms of PD in Bilateral STN Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Change of parameters (voltage, pulse width, frequency) during follow-up
研究概览
简要总结
The purpose of this study is to assess the impact of different parameters (voltage, pulse width, frequency) of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor symptoms in patients with Parkinson's disease (PD).
详细描述
In this observational study, we will retrospectively analyze the one-year follow-up data of 27 PD patients who received bilateral STN DBS in the First Affiliated Hospital of Sun Yat-sen University in the years 2008-2012. The data, including parameter settings and severity of motor symptoms indicated by Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores, was collected during the patients' annual visit to the hospital for reprogramming. A correlation analysis will be conducted to investigate the relationship between change of a specific parameter and the subsequent change of motor scores.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PD patients treated with bilateral STN DBS in the First Affiliated Hospital in the years 2008-2012
排除标准
- •Simultaneous participation in another clinical trial
- •Dementia (Mini Mental State Examination < 26)
- •Removal of DBS electrodes
- •Loss to follow-up
结局指标
主要结局
Change of parameters (voltage, pulse width, frequency) during follow-up
时间窗: at 12 months
Change of UPDRS Part III score and the relation to parameters
时间窗: at 12 months
Changes of tremor, rigidity, bradykinesia and postural stability scores evaluated by UPDRS Part III and the relation to parameters
时间窗: at 12 months
次要结局
- Change of daily levodopa equivalent dosage (LED) during follow-up(at 12 months)
研究者
Chen Ling
MD,PhD
First Affiliated Hospital, Sun Yat-Sen University