Multicenter Prospective Cohort Study on TAM Receptor Tyrosine Kinase Ligands for Predicting the Severity of Acute Pancreatitis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 896
- Locations
- 1
- Primary Endpoint
- Proportion of Participants with Severe Acute Pancreatitis
Study Overview
Brief Summary
AXL and MERTK are homologous members of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family. They function as critical regulators of antiviral immunity, autoimmune responses, and tumor microenvironment modulation through their bridging ligands, GAS6 (Growth Arrest-Specific 6) and PROS1 (Protein S). These receptors serve as damage sensors that negatively regulate inflammation, promote tissue repair/remodeling, and modulate fibrotic processes in chronic inflammatory conditions. Building upon our previous work demonstrating the pivotal role of the AXL/MERTK signaling axis in AP pathogenesis - particularly in pancreatic necrosis regulation, this clinical study seeks to evaluate the prognostic value of the TAM receptor ligands GAS6 and PROS1 as biomarkers for predicting AP severity.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age 18-80 years.
- •Patients diagnosed with acute pancreatitis in outpatient/emergency departments, inpatient wards, or health examination centers starting from 2024.
Exclusion Criteria
- •Patients with chronic pancreatitis or pancreatic cancer.
- •Pregnant or lactating women.
- •Patients who did not provide informed consent.
- •Patients with severe organic diseases, such as malignant tumors, acute myocardial infarction, or large-scale cerebral infarction.
Outcomes
Primary Outcomes
Proportion of Participants with Severe Acute Pancreatitis
Time Frame: 2 days
AP severity was classified as mild (MAP), moderately severe (MSAP), or severe (SAP) according to the revised Atlanta classification.
Secondary Outcomes
- Incidence Rate of Persistent Organ Failure (≥48 Hours) in Acute Pancreatitis(2 days)