NCT07238530已完成不适用
Evaluation of Insulin Resistance in Hepatitis C Infected Thalassemia Children and Survivors of Childhood Malignancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- The primary outcome measure was to study the occurrence of insulin resistance in hepatitis C virus infected children who were either thalassemic or survivors of childhood malignancy
研究概览
简要总结
The goal of this observational study was to study the occurrence of insulin resistance in hepatitis C virus infected children who were either thalassemic or survivors of childhood malignancy and its correlation to the HCV viral load and other metabolic factors.
The main question it aims to answer is:
- Do children infected with Hepatitis C have a higher incidence of Insulin resistance compared to healthy controls of same age and gender?
- Is Insulin resistance occurence affected by HCV viral load, blood transfusion frequency, or metabolic factors? Researchers will compare hepatitis c infected children who are either thalassemic or survivors of childhood malignant to healthy age and sex matched controls.
Participants will be subjected to:
- standardized Questionnaires,
- physical examination and
- laboratory investigations including liver functions (ALT, AST, Alkaline phosphatase), Prothrombin time, serum ferritin level, albumin, fasting glucose, fasting insulin level and Insulin resistance assessment by HOMA IR calculation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •hepatitis C virus ribonucleic acid (RNA) positive children, who were following up at the pediatric hematology and oncology clinic
排除标准
- •patients with concurrent active hepatitis B virus infection (positive for hepatitis B surface antigen) or
- •autoimmune hepatitis,
- •primary biliary cirrhosis (PBC),
- •sclerosing cholangitis,
- •haemochromatosis,
- •α1-antitrypsin deficiency,
- •Wilson's disease,
- •patients with obesity (BMI > 25), or
- •Type 2 DM.
结局指标
主要结局
The primary outcome measure was to study the occurrence of insulin resistance in hepatitis C virus infected children who were either thalassemic or survivors of childhood malignancy
时间窗: over a period of 6 months
Insulin resistance was assessed by using Homeostasis Model Assessment (HOMA) index
次要结局
- Secondary outcome measure was to assess correlation between insulin resistance and HCV viral load and metabolic parameters.(6 months)
研究者
研究点 (1)
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