NCT02407197
Completed
Not Applicable
International T1 Multicentre CMR Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiomyopathy
- Sponsor
- King's College London
- Enrollment
- 1629
- Locations
- 4
- Primary Endpoint
- Survival
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Myocardial fibrosis is the fundamental substrate for the development of heart failure.
Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and T1 mapping.
Patients: Prospective longitudinal observational multicenter study of consecutive patients with suspected or known non-ischemic cardiomyopathy.
Imaging: Non-invasive measures of myocardial fibrosis: native T1, extracellular volume fraction (ECV) and LGE.
Primary endpoints: all cause and cardiovascular mortality.
Secondary endpoints: arrhythmic composite and HF composite endpoints.
Investigators
Eike Nagel
Global Chief Investigator
King's College London
Eligibility Criteria
Inclusion Criteria
- •adults \> 18 years of age
- •clinical indication for CMR
- •able to provide informed consent
- •Exclusion criteria:
- •contraindications for cardiac magnetic resonance imaging due to MR unsafe devices or objects
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Survival
Time Frame: 1 year
number of deaths
Secondary Outcomes
- Rate of deaths due to cardiovascular causes(1 year)
- Rate of HF events(1 year)
- Rate of Arrhythmia(1 year)
Study Sites (4)
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