Evaluation of efficacy of oral versus rectal administration of Panchatikta Ghrita in Plaque Psoriasis : A Randomized Clinical Trial

In the context of today’s fast-paced and stressful lifestyle, diseases linked to improper diet (Ahara), irregular daily routines (Vihara), and environmental pollutants are on the rise. Among them, Psoriasis stands out as a chronic, autoimmune skin disorder influenced by multiple triggers such as psychological stress, incompatible food habits, environmental factors, and certain medications. Characterized by well-defined, scaly, red plaques, Psoriasis affects both men and women equally and is not just a skin-deep condition—it has a profound psychological and social impact. Patients often suffer from low self-esteem, social withdrawal, and emotional distress. With an alarming global prevalence (120–180 million cases) and a reported Indian adult prevalence ranging from 0.44% to 2.8%, psoriasis demands more attention in terms of diagnosis and long-term management. Ayurveda classifies all skin disorders under the term Kushtha, which is broadly divided into two categories: Mahakushtha (major skin disorders) and Kshudra Kushtha (minor skin disorders). The seven types of Kushtha mentioned in Mahakushtha and eleven types of Kshudra Kushtha whereEkakushtha is listed under Kshudra Kushtha and is considered to closely resemble plaque psoriasis, highlighting improper lifestyle and diet as root causes.

Despite various treatment options in modern medicine, many patients remain dissatisfied due to the lack of lasting relief and potential side effects of conventional therapies. A U.S. National Psoriasis Foundation survey revealed that 78% of patients with severe psoriasis expressed frustration with current treatments. This underscores the urgent need for safe, effective, and affordable alternatives. Ayurveda offers a promising solution with its holistic approach and minimal side effects. Panchatikta Ghrita, a classical Ayurvedic formulation, has shown efficacy in managing plaque psoriasis, and while it is traditionally used orally, its rectal administration (basti) may enhance absorption, compliance, and therapeutic outcomes. Considering the need for long-term, palatable treatments, exploring such alternative routes of administration aligns with Ayurvedic principles and can offer sustainable relief, improving both physical symptoms and overall quality of life.