Efficacy of Ultrasound-guided Injection of 5% Dextrose for Meralgia Paresthesia

Not Applicable

Completed

• Conditions: Meralgia Paresthetica
• Interventions: Other: injection

• Registration Number: NCT06251882
• Lead Sponsor: Peking University People's Hospital

Brief Summary

Meralgia paresthetica (MP) is one of the most common peripheral entrapment neuropathies of the lower limbs. It is characterized by paresthesia, pain, tingling, numbness, hypersensitivity, or other abnormal skin sensations on the anterolateral aspect of the thigh. The condition results from compression of the lateral femoral cutaneous nerve (LFCN) along its course, often occurring as the nerve exits the pelvis.The injection of 5% dextrose (D5W) under ultrasound guidance is a novel treatment method for peripheral nerve entrapment. However, there is limited evidence about the efficacy of this method for patients with MP. The investigators found D5W was more safe and effective than corticosteroids for patients with MP. Thus, this study aimed to evaluate the 6-month efficacy of ultrasound-guided injection of D5W for MP patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-01
• Primary Completion: 2023-06-30
• Study Completion: 2024-01-30
• Status Verified: 2024-02
• Study First Submitted: 2024-02-01
• Study First Submitted QC: 2024-02-01
• Last Update Submitted: 2024-02-08
• Study First Posted: 2024-02-09
• Last Update Posted: 2024-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients aged between 18 and 80 years;
• those diagnosed with MP based on clinical and physical examination, with symptoms persisting for at least 3 months;
• a high-resolution ultrasound revealing LFCN compression as it exited the pelvis.

Exclusion Criteria

• MP resulting from trauma, surgery or occupying lesions affecting the LFCN;
• pregnancy;
• concurrent presence of rheumatic immune diseases, hypothyroidism, or diabetes mellitus;
• a known history of allergy to lidocaine or corticosteroids;
• L2/3 lumbar radiculopathy;
• patients who had undergone local injection or surgery for MP within 3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
D5W group	injection	The patients received one session of ultrasound-guided 10ml D5W injection around the lateral femoral cutaneous nerve as it exited the pelvis.

Primary Outcome Measures

Name	Time	Method
visual analogue scale(VAS)	baseline as well as 1month, 3 month, 6 months post-injection	VAS is one of the most common tool to assess pain severity for patients, ranging from 0(no pain) to 10(most possible pain).

Secondary Outcome Measures

Name	Time	Method
cross-sectional area(CSA) of the nerve	baseline as well as 1month, 3 month, 6 months post-injection	CSA could reflect the compression of the nerve, to some extent

Trial Locations

Locations (1)

Peking University People's Hospital; 🇨🇳 Beijing, Beijing, China