ISRCTN88589234已完成3 期
Presurgical metformin for women with endometrial cancer: a randomised placebo controlled trial
Central Manchester University Hospitals NHS Trust (CMFT)0 个研究点目标入组 90 人开始时间: 2015年3月5日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
研究概览
简要总结
2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30563932
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Biopsy-proven type 1 endometrial carcinoma or severe atypical endometrial hyperplasia
- •2. Scheduled surgical treatment by hysterectomy in 5-35 days’ time
- •3. Informed consent
- •4. Age 18 years or more
排除标准
- •1. Current treatment with metformin
- •2. Diabetic on hypoglycaemic medication
- •3. Inability to consent due to lack of capacity or language barriers
- •4. Unable to comply with treatment protocol
- •5. Type 2 endometrial cancer
- •6. Severe renal impairment (Serum creatinine >130umol/L or eGFR < 45ml/min/1.732m2)
- •7. Severe hepatic impairment (abnormal LFTs to be discussed on case by case basis with hepatologist)
- •8. Current alcohol abuse
- •9. Sensitivity/hypersensitivity to biguanides
- •10. Current treatment with other mTOR inhibitors or chemotherapeutic agents
研究者
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