Obesity and Liver Function in Oesophageal Cancer

• Conditions: Liver Function; Obesity
• Interventions: Other: Observation of different types of obesity and liver pathology in patients undergoing and oesophagectomy

• Registration Number: NCT04152044
• Lead Sponsor: St. James's Hospital, Ireland

Brief Summary

There is an established link between sarcopenia and outcomes in oesophageal cancer. There is scant reports in the literature regarding the influences of different obesity in different compartments.

Detailed Description

Oesophageal cancer rates are increasing as a result of obesity in Western society. Thr investigators are evaluating the influence of viscerala dn subcutaneous obesity on overall outcomes of the participants. In addition the investigators are evaluating if there is a correlation with Liver Function Tests and liver histopathology such as steatosis on survival in participants and post operative sequele.

Study Timeline

• Status Verified: 2019-11
• Study Start: 2019-11-01
• Study First Submitted: 2019-11-02
• Study First Submitted QC: 2019-11-02
• Last Update Submitted: 2019-11-02
• Study First Posted: 2019-11-05
• Last Update Posted: 2019-11-05
• Primary Completion: 2020-07-01
• Study Completion: 2020-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 658

Inclusion Criteria

• Those undergoing oesophagectomy

Exclusion Criteria

• patients who only had chemotherapy/chemoradiotherapy without surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Liver biopsy, Visceral and subcutaneous obesity	Observation of different types of obesity and liver pathology in patients undergoing and oesophagectomy	Those with histology and LFT's and quantificaiton of obesity

Primary Outcome Measures

Name	Time	Method
Disease free survival	1 year
Overall Survival	1 year

Trial Locations

Locations (1)

St. James's Hospital; 🇮🇪 Dublin, IE, Ireland