NCT05612893尚未招募不适用
Discover the Immune Signature of Sepsis Caused by Acute Pulmonary Infection: A Cohort Study
Capital Medical University1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2022年11月16日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- upper respiratory infection or pneumonia or Sepsis
研究概览
简要总结
The goal of this observational study is to describe the immune signature of acute pulmonary infection.The main questions it aims to answer are:
- Nasal mucosal immune response in patients with influenza infection
- Difference of immune response between Viral sepsis and Bacterial sepsis
- Immunological differences between Viral sepsis and Viral pneumonia
详细描述
- Aging could influence host immune response. Elderly people are more likely to progress to severe pneumonia than young people. Nasal mucosa is the initial infection site of influenza infection. Single cell sequencing of nasal mucosal cell that may provide valuable insights into host response to influenza infection.
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Although bacteria are considered as the main pathgens of sepsis，SARS-CoV-2 or influenza infection also can cause multiple organ dysfunction which meet the definition of Sepsis 3.0. Viral sepsis has not received enough attention for a long time. It is important to understand the difference between viral sepsis and bacterial sepsis that may help to develop better strategies to diagnose and treat sepsis.
- Viral pneumonia is one of the leading infectious cause of death woldwide.Pneumina is the most common cause of sepsis.The mechanism of viral pneumonia progressing to sepsis needs to be further investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years at time of signing Informed Consent Form
- •chest imaging confirmed pneumonia.
- •Informed consent is obtained
- •The pneumonia onset ≤8 days
排除标准
- •SaO2/SPO2≤94% on room air or Pa02/Fi02 ratio <300mgHg before the onset of pneumonia
- •Severe liver disease (e.g. Child Pugh score ≥ C, AST>5 times upper limit)
- •Patients with known severe renal impairment (estimated glomerular filtration rate ≤30 mL/min/1.73 m2) or receiving continuous renal replacement therapy, hemodialysis,peritoneal dialysis）
- •Pregnant Or Lactating Women
- •Patients were eligible for organ transplantation or had undergone previous organ transplantation surgery
- •HIV infection
- •Had unstable angina or myocardial infarction within 30 days without vascular recanalization treatment
结局指标
主要结局
upper respiratory infection or pneumonia or Sepsis
时间窗: up to 28 days
Patients were grouped and compared according to their diagnosis.
次要结局
- All cause mortality(up to 28 days)
- Length of hospital stay (days)(up to 28 days)
- Clinical status(days 0, 3, 7)
- Length of ICU stay (days)(up to 28 days)
研究者
Bin Cao
Professor
Capital Medical University
研究点 (1)
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