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Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy

Phase 1
Completed
Conditions
Epilepsy
Interventions
Procedure: Stem cell transplantation
Registration Number
NCT00916266
Lead Sponsor
Instituto do Cerebro de Brasilia
Brief Summary

This research investigates the use of autologous bone marrow stem cells for the treatment of medically refractory temporal lobe epilepsy patients.

Detailed Description

The aim of this study is to evaluate autologous bone marrow stem cells transplantation as a safe and potentially beneficial treatment for patients with temporal lobe refractory epilepsy. We are mainly evaluating seizure frequency, hippocampal volume an cognitive performance

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
20
Inclusion Criteria
  • temporal lobe medically refractory epilepsy patients with hippocampal atrophy
Exclusion Criteria
  • under 18 or over 65 years old patients
  • previous neurological surgery
  • other neurodegenerative diseases

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
stem cell transplantationStem cell transplantationPatients with refractory temporal lobe epilepsy that are transplanted with autologous bone marrow stem cells in order to provide seizure control.
Primary Outcome Measures
NameTimeMethod
seizure frequency6 months
Secondary Outcome Measures
NameTimeMethod
adverse effects6 months
hippocampal volume6 months
cognitive performance6 months

Trial Locations

Locations (1)

Instituto do Cerebro

🇧🇷

Porto Alegre, RS, Brazil

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