Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy
Phase 1
Completed
- Conditions
- Epilepsy
- Interventions
- Procedure: Stem cell transplantation
- Registration Number
- NCT00916266
- Lead Sponsor
- Instituto do Cerebro de Brasilia
- Brief Summary
This research investigates the use of autologous bone marrow stem cells for the treatment of medically refractory temporal lobe epilepsy patients.
- Detailed Description
The aim of this study is to evaluate autologous bone marrow stem cells transplantation as a safe and potentially beneficial treatment for patients with temporal lobe refractory epilepsy. We are mainly evaluating seizure frequency, hippocampal volume an cognitive performance
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- temporal lobe medically refractory epilepsy patients with hippocampal atrophy
Exclusion Criteria
- under 18 or over 65 years old patients
- previous neurological surgery
- other neurodegenerative diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description stem cell transplantation Stem cell transplantation Patients with refractory temporal lobe epilepsy that are transplanted with autologous bone marrow stem cells in order to provide seizure control.
- Primary Outcome Measures
Name Time Method seizure frequency 6 months
- Secondary Outcome Measures
Name Time Method adverse effects 6 months hippocampal volume 6 months cognitive performance 6 months
Trial Locations
- Locations (1)
Instituto do Cerebro
🇧🇷Porto Alegre, RS, Brazil