Mini-Mental State (MMS-LS) and Sign Language
- Conditions
- Retention Disorders, CognitivePrelingual Deafness
- Interventions
- Behavioral: application of the mini-mental state test
- Registration Number
- NCT02005679
- Lead Sponsor
- Lille Catholic University
- Brief Summary
In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants.
The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.
- Detailed Description
The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 195
- Adults> 18 years
- Pre-lingual deafness
- Use of French sign language
- Refusal to sign the consent
- Severe visual impairment with lower acuity (less than 0.5)
- Severe motor difficulties impeding the practice of sign language
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description deaf persons with potential dementia application of the mini-mental state test -
- Primary Outcome Measures
Name Time Method Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test At baseline, 1 year and 2 years follow-up visits
- Secondary Outcome Measures
Name Time Method Diagnostic performance and predictive values of MMS-LS test for acquired dementia. Baseline, 1 year and 2 years follow-up visits Sensitivity, specificity, positive and negative predictive values.
Diagnostic performance and predictive values of MMS-LS test for suspected dementia. Baseline, 1 year and 2 years follow-up visits Sensitivity, specificity, positive and negative predictive values
Description of MMS-LS test results Baseline Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members)
Correlation between MMS-LS score and CDR level Baseline, 1 year and 2 years follow-up visits We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1.
Trial Locations
- Locations (4)
Hôpital de la Conception, Pôle psychiatrie Centre
🇫🇷Marseille, Bouches-du-Rhône, France
Groupement des Hôpitaux de l'Institut Catholique de Lille
🇫🇷Lille, Nord Pas De Calais, France
CHU de Rennes, Hôpital de Pontchaillou
🇫🇷Rennes, Ille-et-Vilaine, France
Unité Régionale d'Accueil et de Soins pour Sourds et malentendants - CHRU Nancy
🇫🇷Nancy, Meurthe-et-Moselle, France