Comparison of Aerobic Exercise, Strength Training, or Its Combination in Hemodialysis Patients: a Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- End Stage Renal Disease
- Sponsor
- St. Joseph's Healthcare Hamilton
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- change in walking speed over 20 weeks
- Last Updated
- 10 years ago
Overview
Brief Summary
Study Hypothesis: The combination of aerobic and resistance exercise training will improve walking speed compared to either individual intervention.
Brief Summary:
Sixty hemodialysis participants who meet inclusion and exclusion criteria will be randomized to 20 weeks of supervised exercise, using either: (i) on-dialysis aerobic exercise using a bike ergometer; (ii) pre-dialysis leg strength training using weights; or (iii) both. The primary outcome is walking speed over 4-metres. Secondary outcomes will include:
(i) short physical performance battery; (ii) health-related quality of life [EuroQOL-5D-5L]; (iii) Dialysis recovery time; (iv) Nottingham extended activities of daily living (EADL) index; (v) Leg strength; (vi) body composition and anthropometry.
Investigators
Scott Brimble
Staff Nephrologist/Associate Professor of Medicine
St. Joseph's Healthcare Hamilton
Eligibility Criteria
Inclusion Criteria
- •At least 18 years of age
- •On hemodialysis minimum of 3 times per week
- •On hemodialysis \> 3 consecutive months
Exclusion Criteria
- •Inability to provide consent
- •Inability to walk 4-metres
- •Chest pain with exertion or myocardial infarction in past 6-months
- •Pre-dialysis systolic blood pressure \> 200 mm Hg or diastolic BP \> 100 mm Hg in past 2-weeks
- •Functional or cardiorespiratory limitations preventing use of cycle ergometer for at least five-minutes or the ability to perform single maximum rep with each of resistance exercises described
- •Joint replacement or lower extremity fracture in previous 6-months
- •Severe cognitive impairment
- •Currently using corticosteroids \>5 mg/day
- •Pre-dialysis serum potassium in previous month less than 3.5 or greater than 6.0 mmol/L.
- •Attending nephrologist feels exercise is medically contraindicated
Outcomes
Primary Outcomes
change in walking speed over 20 weeks
Time Frame: 10 and 20 weeks
repeated measures analysis
Secondary Outcomes
- change in short physical performance battery over 20 weeks(10 and 20 weeks)
- change in body anthropometry and composition over 20 weeks.(10 and 20 weeks)
- change in EuroQOL-5D-5L over 20 weeks(10 and 20 weeks)
- change in Nottingham extended activities of daily living index over 20 weeks(10 and 20 weeks)
- change in dialysis recovery time over 20 weeks(10 and 20 weeks)
- death(continuous over 20 weeks)
- change in inflammation measures over 20 weeks(10 and 20 weeks)
- hospitalization(continuous over 20 weeks)