68Ga-Citrate PET of Healthy Volunteers
- Conditions
- Healthy
- Interventions
- Other: Gallium-68 citrate
- Registration Number
- NCT01951300
- Lead Sponsor
- Turku University Hospital
- Brief Summary
This study investigates whole-body distribution kinetics of intravenously administered Gallium-69 (68Ga) citrate by positron emission tomography (PET)/computed tomography (CT). Thereafter, radiation dosimetry of 68Ga-citrate PET/CT will be determined.
- Detailed Description
Six healthy male volunteers are recruited in this study. Gallium-68 citrate radiopharmaceutical is intravenously injected as a bolus and whole-body distribution kinetics are studied by dynamic whole-body positron emission tomography/computed tomography. During imaging, serial venous blood samples are drawn, plasma is separated and radioactivity is measured by gamma counter. Immediately after imaging session, urine is voided and radioactivity is measured by gamma counting. As a final point, radiation dosimetry due to single Gallium-68 citrate injection is determined.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 6
- healthy 18-100 year-old men
- ongoing infection/inflammation proven by blood or other tests
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Gallium-68 citrate Gallium-68 citrate Intravenous bolus injection of 200 MBq of Gallium-68 citrate
- Primary Outcome Measures
Name Time Method Whole-body distribution of Gallium-68 citrate 4 hours
- Secondary Outcome Measures
Name Time Method Absorbed dose 4 hours Absorbed ionisation radiation dose in critical organs due to intravenous bolus injection of 200 MBq of Gallium citrate
Trial Locations
- Locations (1)
Turku University Hospital/Turku PET Centre
🇫🇮Turku, Finland