NCT05612906招募中不适用
Effect of RDN on Renal Function
Zhengrong Huang1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2022年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Changes of serum creatinine and urea nitrogen before and after RDN operation
研究概览
简要总结
Current studies have found the efficacy of RDN in the treatment of hypertension, however, the safety of RDN in renal function is still lacking. Therefore, the investigators are aimed to study the effect of RDN on renal function.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1.18<age≤75 years; 2.clinic blood pressure ≥ 140/90 mmHg or 24-hour ambulatory blood pressure monitoring average blood pressure ≥ 135/85 mmHg after taking 3 or more antihypertensive drugs for more than 4 weeks; 3.essential hypertension, renal parenchymal hypertension, or hypertension patients who are willing to receive RDN ; 4.who signed informed consent and were approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University.
排除标准
- •pregnant women or lactating patients;
- •identified secondary hypertension or Pseudo hypertension;
- •whose renal arteries were unsuitable for ablation
- •obvious bleeding tendency and blood system diseases;
- •malignant tumors or end-stage diseases; ⑥Severe peripheral vascular disease, abdominal aortic aneurysm; ⑦A history of the acute coronary syndrome within two weeks; ⑧acute or severe systemic infection; ⑨drug or alcohol dependence or refusal to sign informed consent.
结局指标
主要结局
Changes of serum creatinine and urea nitrogen before and after RDN operation
时间窗: Baseline,1week/1 month/6months after RDN operation
Serum creatinine(umol/L, ammonia iminohydrolase assay)and urea nitrogen(umol/L, urease methods) were obtained by blood test.
Changes of glomerular filtration rate before and after RDN operation
时间窗: Baseline, 6months after RDN operation
Glomerular filtration rate(ml/min) were obtained by ECT
次要结局
- Effect of RDN operation on renal artery(Baseline, 6months after RDN operation)
- Urinary protein/serum creatinine ratio change before and after RDN operation(Baseline,1week/1 month/6months after RDN operation)
研究者
Zhengrong Huang
Professor
The First Affiliated Hospital of Xiamen University
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Effect of Renal Denervation on Bood Pressure in Patients on HemodialysisTreatment Resistant HypertensionChronic HemodialysisNCT06556407University of Erlangen-Nürnberg Medical School12
进行中（未招募）
不适用
Renal Denervation in ADPKD- RDN-ADPKD StudyUncontrolled HypertensionRenal DenervationAutosomal Dominant Polycystic Kidney DiseaseNCT05460169University of Erlangen-Nürnberg Medical School44
进行中（未招募）
不适用
Renal Denervation in Chronic Kidney Disease - RDN-CKD StudyUncontrolled HypertensionRenal DenervationChronic Kidney Disease stage3NCT04264403University of Erlangen-Nürnberg Medical School44
撤回
不适用
Renal Denervation for Uncontrolled HypertensionHypertensionNCT02016573Baker Heart and Diabetes Institute
终止
不适用
Effect of Caldine® on Renal Function in Balanced HypertensionHypertensionNCT02240641Boehringer Ingelheim5,417