Aging-related memory impairment: a behavior-genomics study

Withdrawn

• Conditions: No disorder: Age-related memory performance; 10042258

• Registration Number: NL-OMON43432
• Lead Sponsor: Takeda

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 220

Inclusion Criteria

1. The subject has to sign and date a written informed consent form prior to the initiation of study procedures;
2. The subject falls in the age-range of one the cohorts, i.e. 18-30; 40-60; 60-80;
3. The subject has good comprehension of the Dutch language
4. Normal memory performance

Exclusion Criteria

- Suffering from uncontrolled, clinically significant neurologic disease or other abnormality which may impact the ability of the subject to participate or potentially confound the study results, which includes pregnancy and having received chemo treatment during the past year.
- The presence of psychiatric illness including schizophrenia, depression, bipolar disorder, Attention Deficit Hyperactivity Disorder and autism;
- Smoking more than 10 cigarettes a day.
- Excessive drinking, i.e. >20 glasses of alcohol containing beverages a week,
- Current use of psychoactive medication (e.g. antidepressants, antipsychotics), centrally acting beta blockers, use of recreational drugs from 2 weeks before until the end of the
yearly testing ,
- Any sensory or motor deficits which could reasonably be expected to affect test performance.
- Consultation of a clinical expert for memory problems before having entered the study
- Having received any investigational compound within 60 days prior to the Baseline
(Screening) Visit

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure is memory decline in the Verbal Learning Test<br /><br>(VLT). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In the eldest group, the Mini Mental State Examination will provide a more<br /><br>global indication on cognitive functioning. For all groups, functioning in<br /><br>related cognitive domains will be assessed using the Visual Association Test,<br /><br>Digit Span, Fluency, Letter Digit Substitution, Stroop, Trail Making Test, and<br /><br>Pattern Separation.</p><br>