One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running
- Conditions
- Magnesium Deficiency
- Interventions
- Dietary Supplement: Magnesium oxideDietary Supplement: Placebo
- Registration Number
- NCT04216836
- Lead Sponsor
- University of Worcester
- Brief Summary
This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.
- Detailed Description
Magnesium status can directly affect circulating glucose concentrations both during and post exercise. In addition, magnesium supplementation has been shown to reduce circulating IL-6 concentrations post exercise in humans. It is conceivable that such observations are linked through the role of IL-6 in glucose regulation, possibly in combination with sIL-6R. Together, magnesium intake may have the potential to effect exercise performance and recovery through glucose availability. This in turn may be connected to the production of IL-6 and sIL-6R which have been established to influence exercise fatigue and perception of pain (muscle soreness).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 9
- Regular recreational runner, running around 3 times per week
- Capable of running 10 km in ~ 40 minutes.
- Any signs or symptoms of cardiovascular issues.
- Any recent form of injury or illness.
- Currently, or in the last 3 months, have consumed multivitamin supplements
- Currently, or in the last 3 months, have consumed anti-inflammatory medications.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description High magnesium diet (SUP condition) Magnesium oxide Participants followed a low magnesium diet \<260mg/day and consumed 500 mg/day of magnesium oxide. This was separated into 3 capsules, which were consumed at 6 hr intervals each day (8am, 2pm and 8pm). The supplementation period was 1 week. Low magnesium diet (CON condition) Placebo Participants followed a low magnesium diet \<260mg/day and consumed 500 mg/day of placebo (cornflour). This was separated into 3 capsules, which were consumed at 6 hr intervals each day (8am, 2pm and 8pm). The supplementation period was 1 week.
- Primary Outcome Measures
Name Time Method 24 hr post exercise maximal force testing of the dominant leg on the isokinetic dynamometer 1 day Maximal force produced from the dominant leg (eccentric and concentric) on an isokinetic dynamometer.
Downhill 10 km treadmill time trial performance 1 day Maximal 10 km time trial performance on a treadmill
- Secondary Outcome Measures
Name Time Method Interleukin-6 up to 2 days Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse interleukin-6.
Lactate up to 2 days Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse lactate concentrations.
Glucose up to 2 days Capillary blood samples at rest, during, immediately post, 1 hr post and 24 hrs post 10 km downhill time-trial. A Biosen analyser was used to analyse glucose concentrations.
Perceived muscle soreness up to 4 days A 10cm visual analogue scale was used to assess perceived muscle soreness, the scale started at 0 (no pain) and finished at 10 (unbearable pain)
Creatine kinase up to 2 days Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. A Reflotron analyser was used to analyse creatine kinase concentrations.
Soluble interleukin-6 receptor up to 2 days Venous blood samples at rest, immediately post, 1hr post and 24 hrs 10 km downhill time trial. Enzyme-linked immunosorbent assays were used to analyse soluble interleukin-6.
Trial Locations
- Locations (1)
University of Worcester
🇬🇧Worcester, Worcestershire, United Kingdom