Therapeutic use of transcranial Alternating Current Stimulation for Obsessive Compulsive Disorder

Not Applicable

• Conditions: Obsessive compulsive disorder; Mental Health - Anxiety

• Registration Number: ACTRN12620000748910
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-07-21
• Study Completion: 2022-08-25
• Last Update Posted: 12 December 2022

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• 18-65 years of age.
• Diagnosis of OCD, in accordance with the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5).
• Have not initiated new OCD treatment (pharmacological or behavioural) or increased dosage of current psychopharmacological treatment in the past 6 weeks.
• Demonstrated capacity to give informed consent.

Exclusion Criteria

• Are currently pregnant or breastfeeding.
• Presence of metal (screws, clips) anywhere in the head, except the mouth.
• Have an unstable medical condition or a neurological disorder.
• Have been diagnosed with another personality or psychiatric disorder except depression or another anxiety disorder.
• Unable to provide informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in clinical severity of OCD, as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)[Assessed at baseline, 3-week, 6-week and 3-month follow-up appointments]

Secondary Outcome Measures

Name	Time	Method
Changes in overall cognitive ability, which will be assessed using a battery of cognitive tests (composite outcome). Following are the cognitive tests that will be used:<br>Response inhibition – Go/NoGo task<br>Working memory – n-back task<br>Selective attention – Auditory selective attention task<br>Processing speed – Symbol search[Assessed at baseline, 3-week, 6-week and 3-month follow-up appointments];Change in event related potentials (error related negativity and N200) as measured by EEG[EEG recording at baseline and post-treatment (at 6 weeks)];Change in overall anxiety symptoms as measured by the Beck Anxiety Inventory.[Assessed at baseline, 3-week, 6-week and 3-month follow-up appointments];Change in overall depressive symptoms as measured by Quick Inventory of Depressive Symptoms – self report[Assessed at baseline, 3-week, 6-week and 3-month follow-up appointments]