Skeletal muscle metabolism and Critical Illness Myopathy (CIM) during early course of systemic inflammatio
- Conditions
- Critical illness myopathy (CIM)Signs and SymptomsCritical Illness Myopathy (CIM)
- Registration Number
- ISRCTN77569430
- Lead Sponsor
- Charité - University Medicine Berlin (Charité - Universitätsmedizin Berlin) (Germany)
- Brief Summary
2013 Results article in http://www.ncbi.nlm.nih.gov/pubmed/23239154 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/24651840 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/24531339 results 2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/25263070 results 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/31441598/ (added 01/06/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35922829/ Retrospective analysis (added 04/08/2022)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 80
Critically ill patients with the Sequential Organ Failure Assessment (SOFA) score greater than or equal to 8 on 3 of the 5 successive days within 7 days after admission to ICU.
1. Patients under age of 18
2. Missing written informed consent from a legal proxy
3. Pretreatment in ICU >7 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Primary outcome measures for both observational and interventional studies:<br><br> Insulin sensitivity:<br> 1. Studies of the insulin receptor pathways such as IRS, PI3K, AKT and Glut4 will be performed<br> 2. Glucose uptake as well as Insulin-Receptor kinase and PI3Kinase-activities will be determined<br> 3. Hyperinsulinemic-euglycemic clamp will be performed<br><br> Histopathology on muscle biopsies: Type II myosin loss will be investigated<br>
- Secondary Outcome Measures
Name Time Method <br> Secondary outcome measure for both observational and interventional studies:<br><br> Electrophysiology: Measurement of membrane excitability<br>