A Study to Compare S-217622 With Placebo in Non-Hospitalized Participants With COVID-19
- Registration Number
- NCT05305547
- Lead Sponsor
- Shionogi
- Brief Summary
The main aim of this study is to evaluate the efficacy of S-217622 versus placebo among outpatient adults with mild and moderate COVID-19 starting intervention within 3 days of symptom onset.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2093
- Documentation of laboratory-confirmed active SARS-CoV-2 infection, as determined by a nucleic acid (for example, reverse-transcriptase PCR) or antigen test from any respiratory tract specimen (for example, oropharyngeal, NP or nasal swab, or saliva) collected ≤72 hours (3 days) prior to randomization.
- Participants are expected to begin study intervention ≤3 days from self-reported date of onset of any of the COVID-19-related symptoms from the following list:
- Cough
- Shortness of breath or difficulty breathing
- Feeling feverish
- Chills
- Fatigue
- Body pain or muscle pain or aches
- Diarrhea
- Nausea
- Vomiting
- Headache
- Sore throat
- Nasal obstruction or congestion
- Nasal discharge
- Loss of taste
- Loss of smell
- One or more of the following signs/symptoms present within 24 hours prior to randomization:
- Cough
- Shortness of breath or difficulty breathing
- Feeling feverish
- Chills
- Fatigue
- Body pain or muscle pain or aches
- Diarrhea
- Nausea
- Vomiting
- Headache
- Sore throat
- Nasal obstruction or congestion
- Nasal discharge
- Participants at higher risk of progression to severe COVID-19 are defined as follows:
- Age ≥65 years
- Age ≥18 with 1 of the following:
- Obesity (body mass index [BMI] ≥30 kilograms per square meter [kg/m^2]). Note: BMI is rounded to the nearest whole number, for example 29.5 kg/m^2 is rounded to 30 kg/m^2.
- Diabetes mellitus
- Hypertension requiring daily prescribed therapy
- Cardiovascular disease (requiring daily prescribed therapy or congenital heart disease)
- Chronic lung disease (for example, chronic obstructive pulmonary disease, moderate to severe asthma, interstitial lung disease, cystic fibrosis, pulmonary hypertension) requiring daily prescribed therapy
- Chronic kidney disease, defined as known current kidney impairment with a creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) <60 milliliters (mL)/minute (min)/1.73 square meter (m^2) within the past 12 months prior to randomization, as long as the participant does not have known CrCl <30 mL/min by Cockcroft-Gault or require dialysis
- Down syndrome
- Sickle cell disease
- One of the following immunocompromising conditions or immunosuppressive treatments:
- Receiving chemotherapy or other therapies for cancer
- Hematologic malignancy (active or in remission)
- History of a hematopoietic stem cell or a solid organ transplant
- Human immunodeficiency virus infection: not on antiretroviral therapy or with cluster of differentiation 4+ cell count <200 cells per cubic millimeter
- Combined primary immunodeficiency disorder
- Taking immunosuppressive medications (for example, drugs to suppress rejection of transplanted organs or to treat rheumatologic and gastrointestinal conditions, such as anti-tumor necrosis factor agents, mycophenolate, and rituximab).
Note: Current use of some corticosteroids is exclusionary, due to concern for possible drug-drug interaction (DDI) with S-217622.
- History of hospitalization for the current SARS-CoV-2 infection (that is, prior hospitalization for a prior episode of SARS-CoV-2 infection is allowable)
- For the current SARS-CoV-2 infection, any positive SARS-CoV-2 molecular (nucleic acid) or antigen test from any respiratory tract specimen (for example, oropharyngeal, NP, or nasal swab, or saliva) collected ˃72 hours (3 days) prior to randomization. Participants with reinfection, defined as prior SARS-CoV-2 infection that began >90 days prior to the current onset of symptoms with interval resolution of symptoms are eligible as long as the current infection has not been present for more than 3 days prior to randomization.
- Current need for hospitalization or immediate medical attention in the opinion of the investigator
- Current use of any medications prohibited with the study intervention. Individuals who have used Paxlovid or any other oral, inhaled, or injectable medication intended to treat the current SARS-CoV-2 infection before randomization are excluded. After randomization, locally available SARS-CoV-2 treatment (including but not limited to molnupiravir, mAbs, outpatient IV remdesivir, convalescent plasma, inhaled budesonide, favipiravir, and fluvoxamine) will be permitted, as long as there are no concerns for DDIs.
Note: Paxlovid use for a prior episode of COVID-19 is permitted.
- Receipt of any investigational treatments for the current episode of SARS-CoV-2 at any time prior to randomization is exclusionary. Note: This does not include drugs approved for other uses and taken for those indications or COVID-19 vaccines. Note: Use of locally authorized or approved therapies to prevent COVID-19, such as mAbs given solely to prevent COVID-19, are not exclusionary.
- Any co-morbidity requiring surgery within 7 days prior to randomization or that is considered life threatening in the opinion of the investigator within 28 days prior to randomization
- Known allergy/sensitivity or any hypersensitivity to components of S-217622 or placebo for S-217622
- Known (within 12 months prior to randomization) renal impairment defined as CrCl <30 mL/min by Cockcroft-Gault or requiring dialysis
- Known history of cirrhosis or liver decompensation (including ascites, variceal bleeding, or hepatic encephalopathy)
- Participants who have used any of the following drugs within 14 days prior to randomization:
- Strong cytochrome P453A inducer
- Products containing St. John's Wort
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description S-217622 S-217622 S-217622 will be administered orally for 5 days. Placebo Placebo Placebo matching to S-217622 will be administered orally for 5 days.
- Primary Outcome Measures
Name Time Method Median Time to Sustained Symptom Resolution Up to Day 29
- Secondary Outcome Measures
Name Time Method Change From Baseline in Quantitative log10 SARS-CoV-2 RNA Levels by Polymerase Chain Reaction (PCR) on Nasopharyngeal (NP) Swab at Day 4 Baseline, Day 4 Percentage of Participants With Adjudicated Hospitalization Due to COVID-19 or Death Due to Any Cause Up to Day 29 Percentage of Participants With Detectable SARS-CoV-2 by Viral Culture on NP Swab at Day 4 Day 4 Percentage of Participants With Hospitalization (All Cause) or Death Due to Any Cause Up to Day 29 Percentage of Participants With Detectable SARS-CoV-2 by Viral Culture on NP Swab at Day 8 Day 8 Percentage of Participants With NP SARS-CoV-2 RNA Levels by Quantitative PCR Below the Lower Limit of Quantification on Days 4 and 8 Days 4 and 8 Median Change From Baseline of SARS-CoV-2 RNA by Quantitative PCR in NP Swabs on Day 8 Baseline, Day 8 Median Time to Self-Reported Return to Usual (Pre-COVID-19) Health Up to Day 29 Percentage of Participants Reaching a Score ≥2, ≥3, ≥4, ≥5, ≥6, ≥7, or ≥8 on the Ordinal Scale Up to Day 29 Change From Baseline in Resting Peripheral Oxygen Saturation at Day 29 Baseline, Day 29 Percentage of Participants With Resting Peripheral Oxygen Saturation ≥96% Up to Day 29 Percentage of Participants Exhibiting Persistent Symptoms and Clinical Sequelae Up to Week 24 Percentage of Participants With Symptomatic Viral Rebound as an Increase in Quantitative NP SARS-CoV-2 Viral Culture or NP SARS-CoV-2 RNA Levels by Quantitative PCR After Day 4 up to Day 29 Day 4 up to Day 29 Percentage of Participants With Viral Rebound as an Increase in Quantitative NP SARS-CoV-2 Viral Culture or NP SARS-CoV-2 RNA Levels by Quantitative PCR After Day 4 up to Day 29 Day 4 up to Day 29 Number of Participants With Adverse Events Up to Week 24 Change From Baseline in Short Form 36 Version 2.0 (SF-36 V2) Quality of Life Score Baseline, Week 24 Change From Baseline in EuroQol 5 Dimension 5 Level (EQ-5D-5L) Index Score Baseline, Week 24 Change From Baseline in Post-Acute COVID-19 Questionnaire Baseline, Week 24 Percentage of Participants Who Experienced Death Due to Any Cause Up to Week 24
Trial Locations
- Locations (187)
Miami Clinical Research
🇺🇸Miami, Florida, United States
Vista Health Research, LLC
🇺🇸Miami, Florida, United States
Tagore Hospital & Research Institute
🇮🇳Jaipur, Rajasthan, India
Saveetha Medical College and hospital
🇮🇳Chennai, Tamil Nadu, India
Akram Medical Complex
🇵🇰Lahore, Punjab, Pakistan
Quantum Clinical Trials, 333 Arthur Godfrey Road, Suite 202, suite 208
🇺🇸Miami Beach, Florida, United States
Lakeview Clinical Research
🇺🇸Guntersville, Alabama, United States
Voyage Medical Services
🇺🇸Tempe, Arizona, United States
Novak Clinical Research
🇺🇸Tucson, Arizona, United States
Hope Clinical Research
🇺🇸Canoga Park, California, United States
Carbon Health
🇺🇸Culver City, California, United States
Ark Clinical Research (PARENT)
🇺🇸Long Beach, California, United States
UCSD Antiviral Research Center
🇺🇸San Diego, California, United States
University of California San Francisco (PARENT)
🇺🇸San Francisco, California, United States
Clinical Trials Management Services, 223 E. Thousand Oaks Blvd.
🇺🇸Thousand Oaks, California, United States
Lundquist Institute for BMI, UCLA Medical Center
🇺🇸Torrance, California, United States
University of Colorado Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
Whitman-Walker Health
🇺🇸Washington, District of Columbia, United States
Combined Research Orlando Phase I-IV
🇺🇸Orlando, Florida, United States
Accel Research Sites Network, Ormond Clinical Research Unit, 77 West Granada Boulevard
🇺🇸Ormond Beach, Florida, United States
Clinical Research Center of Florida, 550 SW 3rd St.,, Suite #305
🇺🇸Pompano Beach, Florida, United States
Invictus Clinical Research Group, LLC
🇺🇸Pompano Beach, Florida, United States
Santos Research Center, CORP
🇺🇸Tampa, Florida, United States
Masters of Clinical Research
🇺🇸Augusta, Georgia, United States
Rush University Infectious Diseases
🇺🇸Chicago, Illinois, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
The Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
Infusion Associates
🇺🇸Grand Rapids, Michigan, United States
AB Clinical Trials
🇺🇸Las Vegas, Nevada, United States
Renal Medicine Associates
🇺🇸Albuquerque, New Mexico, United States
Columbia University Irving Medical Center Division of Infectious Diseases
🇺🇸New York, New York, United States
NY Blood Center Project ACHIEVE
🇺🇸New York, New York, United States
University of Rochester Medical Center
🇺🇸Rochester, New York, United States
UNC Global Infectious Diseases
🇺🇸Chapel Hill, North Carolina, United States
OnSite Clinical Solutions, LLC
🇺🇸Charlotte, North Carolina, United States
Burke Primary Care
🇺🇸Morgantown, North Carolina, United States
Progressive Medicine of the Triad, LLC
🇺🇸Winston-Salem, North Carolina, United States
WellNow Urgent Care and Research
🇺🇸Cincinnati, Ohio, United States
Ohio State University College of Medicine
🇺🇸Columbus, Ohio, United States
Infectious Disease Clinical Trials Unit-University of Pennsylvania Health System
🇺🇸Philadelphia, Pennsylvania, United States
UPMC Eye Center - Eye and Ear Institute
🇺🇸Pittsburgh, Pennsylvania, United States
Vanderbilt Health-One Hundred Oaks
🇺🇸Nashville, Tennessee, United States
Central Texas Medical Research
🇺🇸Austin, Texas, United States
Care United Research, 375 North FM 548, suite 100
🇺🇸Forney, Texas, United States
Valley Institute of Research
🇺🇸Fort Worth, Texas, United States
Accurate Clinical Management, LLC
🇺🇸Houston, Texas, United States
Sun Research Institute, LLC
🇺🇸San Antonio, Texas, United States
Progressive Clinical Research
🇺🇸Bountiful, Utah, United States
Clinical Research Partners LLC
🇺🇸Richmond, Virginia, United States
CINME Centro Investigaciones Metabolicas, Pres. Jose Evaristo Uriburu 754, Piso 3 dpto 12
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Sanatorio De La Trinidad, Mitre Bartolome Mitre
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano sede Central, Tte. Gral. Juan Domingo Perón 4190
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Centro Privado de Medicina Familiar, Mindout Research
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Centro De Investigaciones
🇦🇷Mar De Plata, Buenos Aires, Argentina
DIM Clínica Privada, Belgrano 136 - 5to piso
🇦🇷Ramos Mejía, Buenos Aires, Argentina
Hospital General Agudos Dr. J.M., Grl Justo José de Urquiza 609 2do piso, Pabellón Clínica Médica, Enf. Emergentes
🇦🇷Ramos Mejía, Buenos Aires, Argentina
Clínicas Zárate, F. Andrade 332
🇦🇷Zarate, Buenos Aires, Argentina
Sanatorio Privado ,Duarte Quiros
🇦🇷Quiros, Cordoba, Argentina
Instituto Médico de la, Fundación Estudios Clínicos, Italia 428, Rosario
🇦🇷Rosario, Sante Fe, Argentina
Clinica Mayo UMCB
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Sanatorio Allende, Av.
🇦🇷Cordoba, Argentina
Mendoza 2612, Rosario
🇦🇷Santa Fe, Argentina
AMB3 Servicos Medicos Ltda Rua Campinas
🇧🇷Cuiabá, Mato Grosso, Brazil
Faculdade de Medicina da univ., Federal, Av Alfredo Balena, 190, 1° andar - sala 161
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Hosp Nossa Senhora das Gracas, Rue Alcides Munhoz
🇧🇷Curitiba, Paraná, Brazil
Instituto Atena de Psequisa Clinica Ltds, Av Marechal Floriano Peixoto
🇧🇷Natal, Rio Grande Do Norte, Brazil
Thainá Garbino dos Santos, Avenida Protásio Alves 211, Bloco C
🇧🇷Porto Alegre, Rio Grande Do Sul,, Brazil
IPARGS, Rua Antonio Joaquim Mesquita
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Instituto de Pesquisa Clinica de Campinas IPECC Tua Oswaldo
🇧🇷Campinas, Sao Paolo, Brazil
Cecip Jau
🇧🇷Jau, Sao Paolo, Brazil
Instituto de Molestast Cardiovasculares
🇧🇷Tatui, Sao Paolo, Brazil
Fundação Pio XII - Hospital de Amor de, Barretos; Rua Antenor Duarte Villela
🇧🇷Baretos, Sao Paulo, Brazil
Unid Pesquisa Clínica Facultad Medicina, de Botucatu UNESP, Rua Prof. Dr. Armando,Alves s/n, Distrito de rubião Junior
🇧🇷Botucatu, Sao Paulo, Brazil
Hospital Universario Sao Francisco, na Providencia de Deus-Av. Sao Francisco de Assis
🇧🇷Bragança Paulista, Sao Paulo, Brazil
Pesquisare Saude
🇧🇷Santo André, Sao Paulo, Brazil
Hospital da Puc Campinas, Centro de Pesquisa Sao Lucas
🇧🇷Campinas, Brazil
IBPClin, Rua da Gloria
🇧🇷Rio de Janeiro, Brazil
INI/Fiocruz
🇧🇷Rio de Janeiro, Brazil
Programa de estudios y control de, enfermedades tropicales PECET, Carrera 53 N°61-30 Torre 2, Lab. 632
🇨🇴Medellín, Antioquia, Colombia
Centro de Investigación Medico, Asistencia - CIMEDICAL S.A.S, Cra 49C # 82-120
🇨🇴Barranquilla, Atlantico, Colombia
Corazon IPS S.A.S, Carrera 49 No 74 - 158
🇨🇴Barranquilla, Atlantico, Colombia
IPS CENTRO CIENTIFICO ASISTENCIAL S.A.S, Cra 45 #85-49
🇨🇴Barranquilla, Atlántico, Colombia
Centro de investigación en Reumatología, y Especialidades Medicas S.A.S, CIREEM S.A.S.-Cra. 12#97-32
🇨🇴Bogota, Bogotá, Colombia
Fundación Centro Excelencia en Enferm., Crónicas No Transmisibles-FUNCENTRA, CRA 3 N°21 44 B,
🇨🇴Chuchurubi Monteria, Cordoba, Colombia
TyC Inversiones SAS Grupsalud 33-6 IPS, Avenida Libertador # 30-360, Barrio San Pedro Alejandrino
🇨🇴Santa Marta, Magdalena, Colombia
Fundación Cardiomet Cequin,, Street 18 North # 14-25,
🇨🇴Armenia, Quindío, Colombia
BlueCare Salud SAS
🇨🇴Bogota, Colombia
Navrongo Health Research Cntr
🇬🇭Upper East, Navrongo, Ghana
Kintampo Health Research Cntr
🇬🇭Kintampo, Ghana
Kumasi Centre for Research, South End Asuogya Road, Kwame Nkrumah University
🇬🇭Kumasi, Ghana
St. Theresa's Hospital
🇮🇳Hyderabad, Andhra Pradesh, India
DEC-Health Care Hospital
🇮🇳Nellore, Andhra Pradesh, India
Vijaya Super Speciality Hospital
🇮🇳Nellore, Andhra Pradesh, India
King George Hospital
🇮🇳Visakhapatnam, Andhra Pradesh, India
Indira Gandhi Inst of Medical Sciences
🇮🇳Patna, Bihar, India
Sir Ganga Ram Hospital
🇮🇳New Delhi, Delhi, India
Sangini Hospital 1st Flr & 7th flr
🇮🇳Ahmedabad, Gujarat, India
Unity Hospital, Nr. D.R. World
🇮🇳Surat, Gujarat, India
Aman Hospital and Research Center
🇮🇳Vadodara, Gujarat, India
Rhythm Heart Institute - A Unit Of SLPL
🇮🇳Vadodara, Gujarat, India
ESIC Medical College & Hospital
🇮🇳Faridabad, Haryana, India
Sarvodaya Hospital and Research Centre
🇮🇳Faridabad, Haryana, India
BGS Global institute of Medical Sciences
🇮🇳Bangalore, Karnataka, India
KLEs Dr. Prabhakar Kore Hospital & MRC Belagavi
🇮🇳Belgaum, Karnataka, India
Sri Lakshmi Super Speciality Hospital
🇮🇳Bengaluru, Karnataka, India
Shettys Hospital
🇮🇳Bengaluru, Karnataka, India
Sri Venkateshwara Hospitals, SKY HEIGHTS, Site#1/2, Sarjapura-Attibele, Main rd, Indelebele Village
🇮🇳Bengaluru, Karnataka, India
Yenepoya Med College Hosp, EMD Building, 5th fl., University Rd, Deralakatte
🇮🇳Mangalore, Karnataka, India
BAJ RR Hosp and Res Cntr
🇮🇳Dombivli, Maharashtra, India
Suyog Hospital, CR Dept, 2nd flr, B-wing
🇮🇳Nashik, Maharashtra, India
Chopda Medicare & Research Centre Pvt. Ltd
🇮🇳Nashik, Maharashtra, India
Grant Medical Foundation
🇮🇳Pune, Maharashtra, India
J Govt Medical College & Sassoon, Gen Hospitals 1st Floor, ENT department, PGP Hall, Jai Prakash Narayan Road
🇮🇳Pune, Maharashtra, India
Lifepoint Multispecialty Hosp.
🇮🇳Pune, Maharashtra, India
Aakash Healthcare Private Limited
🇮🇳Dwarka, New Delhi, India
Mavens' Hospital Ground Floor N 37, Opp Reliance Fresh, Vaishali Nagar
🇮🇳Ajmer, Rajasthan, India
JNUIMSRC
🇮🇳Jaipur, Rajasthan, India
Voluntary Health Services Infectious Diseases Medical CEN CART Clinical Research Site
🇮🇳Chennai, Tamilnadu, India
Department of Medicine
🇮🇳Kanpur, Uttar Pradesh, India
HB Specialty Hosp. & Res Inst.
🇮🇳Rudrapur, Uttarakhand, India
Calcutta School of Tropical Medicine
🇮🇳Kolkata, West Bengal, India
Ruby General Hospital Limited
🇮🇳Kolkata, West Bengal, India
Kohokai Takagi Hospital
🇯🇵Okawa-shi, Fukuuoka-Ken, Japan
Tsuchiura Beryl Clinic
🇯🇵Tsuchiura-shi, Ibaraki-Ken, Japan
University of Tsukuba Hospital
🇯🇵Tsuchiura-shi, Ibaraki-Ken, Japan
Tashiro Endocrinology Clinic
🇯🇵Tsukuba-shi, Ibaraki-Ken, Japan
Rinku General Medical Center
🇯🇵Izumisano-shi, Osaka-Fu, Japan
Kodaira Hospital
🇯🇵Toda-shi, Saitama-Ken, Japan
Moi University Clin Res Centre, 2nd Fl, Chandaria Chronic, Disease and Cancer Centre
🇰🇪Eldoret, Kenya
Johns Hopkins Research Project, Queen Elizabeth Central Hospital
🇲🇼Chipatala Avenue, Blantyre, Malawi
Mangochi PHNG Study Site, Kamuzu University of Health Sciences, Private Bag 360, Room 805
🇲🇼Mangochi, Malawi
CAIMED Investigación en Salud, S.A. de C.V., Manzanillo #100. Piso 2. Roma Sur
🇲🇽Cuauhtémoc, Cdmx, C.P, Mexico
Instituto Veracruzano, en Investigación Clínica S.C., Sabino s/n, Colonia Reserva Tarimoya ll
🇲🇽Veracruz, CP, Mexico
Avenida Universidad 1001, Edificio 19, planta baja, colonia Chamilpa
🇲🇽Cuernavaca, Morelos, Mexico
Oaxaca Site Management Organization S.C., Humboldt 302, Col. Centro.
🇲🇽Oaxaca de Juárez, Oaxaca, Mexico
Centro Inv. y Avances Med Especializados, (CIAME) Av. Kabah, Lote 38, 39 y 41., Manzana 4, supermanzana 44. Col., Alborada, Benito Juárez
🇲🇽Cancún, Q. Roo, Mexico
FAICIC S. DE R.L. DE C.V., Av. 16 de Septiembre 1165
🇲🇽Ricardo Flores Magón, Veracruz, Mexico
Hospital Cardiológica Aguascalientes, Ecuador 200 Fracc Las Américas
🇲🇽Aguascalientes, Mexico
Centro de Inv. Médica Aguascalientes, (CIMA) Av. Independencia 2130, Int. A. Trojes de Alonso
🇲🇽Aguascalientes, Mexico
Indus Hospital and Health Network
🇵🇰Korangi, Karachi, Pakistan
Rehman Medical Institute Clinical Trial Unit
🇵🇰Hayatabad, Peshawar, Pakistan
Central Park Teaching Hospital
🇵🇰Lahore, Punjab, Pakistan
National Hospital & Medical Center
🇵🇰Lahore, Punjab, Pakistan
The Aga Khan University
🇵🇰Karachi, Sindh, Pakistan
Shifa International Hospital, 4 Pitras Bukhari Rd, H-8/4, H-8
🇵🇰Islamabad, Pakistan
Dow Univ of Health Sciences Ojha Campus
🇵🇰Karachi, Pakistan
Sindh Infectious Disease Hospital and research Centre
🇵🇰Karachi, Pakistan
Maroof International Hospital
🇵🇰Peshawar, Pakistan
Mary Mediatrix Medical Cntr
🇵🇭Lipa, Batangas, Philippines
Mary Johnston Hospital, 1221 Juan Nolasco Street
🇵🇭Tondo, Manila, Philippines
Iloilo Doctors' Hospital, Room 706, New Condoclinics Bldg, West Ave
🇵🇭Lloilo, Molo, Philippines
The Medical City Clark, #100Eatwick, Gatewick, Global Gateway Logistics City, Industrial Estate 5, Clark Freeport Zone
🇵🇭Mabalacat, Pampanga, Philippines
Ilocos Training and Regional Medical Center
🇵🇭La Union, San Fernando, Philippines
Green City Medical Center
🇵🇭Pampanga, San Fernando, Philippines
Healthlink Iloilo, Inc., No. 12, Mabini Str.
🇵🇭Iloilo City, Philippines
Health Cube Medical Clinics, High Pointe Medical Hub, 241 Shaw Blvd
🇵🇭Mandaluyong, Philippines
Lung Center of the Philippines
🇵🇭Quezon City, Philippines
Ostrowieckie Centrum Medyczne
🇵🇱Ostrowiec Świętokrzyski, Poland
Medicome sp. z o.o.
🇵🇱Oświęcim, Poland
Centrum Medyczne "Medyk"
🇵🇱Rzeszów, Poland
Clinmedica Research sp. z o.o.
🇵🇱Skierniewice, Poland
Centrum Badań Klinicznych
🇵🇱Wrocław, Poland
JOSHA Research
🇿🇦Bloemfontein, Free State, South Africa
Newton Clinical Research Centre
🇿🇦Johanesburg, Gauteng, South Africa
Worthwhile Clinical Trials
🇿🇦Johannesburg, Gauteng, South Africa
(PHRU), New Nurses Home 9th floor Chris
🇿🇦Johannesburg, Gauteng, South Africa
CHRU, Themba Lethu Clinic
🇿🇦Johannesburg, Gauteng, South Africa
Ubuntu Clinical Research
🇿🇦Lenasia, Gauteng, South Africa
T/A Midrand Medical Centre, Shop #1, Health Emporium
🇿🇦Midrand, Gauteng, South Africa
Global Clinical Trials
🇿🇦Pretoria, Gauteng, South Africa
Right to Care Research Esizayo, Right Clinic Esizayo
🇿🇦Randburg, Gauteng, South Africa
Limpopo Clin Res Initiative Tamboti Medical Centre
🇿🇦Thabazimbi, Limpopo, South Africa
The Arum Institute NPC Rustenburg CRS
🇿🇦Rustenburg, North West, South Africa
Task Eden Research Centre
🇿🇦George, Western Cape, South Africa
Be Part Research PTY (LTD)
🇿🇦Paarl, Western Cape, South Africa
Roodepoort Medicross Clinical Research Centre
🇿🇦Roodepoort, South Africa
Siriraj Hospital
🇹🇭Bangkok Noi, Bangkok, Thailand
Thai Red Cross AIDS Research Centre
🇹🇭Pathum Wan, Bangkok, Thailand
Research Institute for Health Sciences
🇹🇭Mueang Chiang Mai District, Chiang Mai, Thailand
Srinagarind Hospital
🇹🇭Mueang Khon Kaen District, Khon Kaen, Thailand
Hacettepe Universitesi Tip Fakultesi, Hacettepe Universitesi Tip Fakultesi
🇹🇷Altındag, Ankara, Turkey
Dicle University Medical Faculty, Infectious Diseases Hospital Floor:5, Clinical Research Room
🇹🇷Sur, Diyarbakir, Turkey
Acibadem Atakent Hospital
🇹🇷Kucukcekmece, Instanbul, Turkey
Infectious Diseases Institute (IDI), Mulago Hill Road
🇺🇬Kampala, Uganda
Joint Clinical Research Centre
🇺🇬Kampala, Uganda
SICRA, Lira Regional Referral, Plot 21-41 Ngetta Road P.O. Box 330062
🇺🇬Lira, Uganda
IDRC Clinic, Tororo General Hospital, P.O. Box 2, Station Rd
🇺🇬Tororo, Uganda