A randomized, placebo controlled trial on the effect of intranasal corticosteroid as a treatment for moderate to severe obstructive sleep apnea with coexisting chronic rhinitis

Not Applicable

Active, not recruiting

• Conditions: Moderate to severe obstructive sleep apnea with chronic rhinitis; Moderate to severe obstructive sleep apnea; chronic rhinitis; apnea hypopnea index; intranasal steroid

• Registration Number: TCTR20180614004
• Lead Sponsor: ONE

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-06-01
• Study Start: 2018-06-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

1. 20-65 year old volunteers
2. Polysomnography test with apnea-hypopnea index at least 15 events per hour
3. Total nasal symptom score questionnaire required more than 6
4. Skin test required
5. Modified Mallampati grade 1-2

Exclusion Criteria

1. Without serious co-morbidity disease; resistant hypertension, poor controlled cardiovascular disease, cerebrovascular disease
2. Morbid obesity; body mass index was more than 30 kg/m2
3. Oral appliance or continue positive airway pressure previous used
4. Bi-level positive airway pressure used
5. Previous intranasal steroid used within 3 months of research period
6. Could not attend 2 appointments and poor technique of drug used
7. Could not discontinue anti-allergy drug within 7 days of before enrollment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
apnea hypopnea index 1 month polysomnography test

Secondary Outcome Measures

Name	Time	Method
sleep quality 1 month questionnaire