Elucidating the Effects of Cannabis on Cardiovascular System
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Inflammation
研究概览
简要总结
Cannabis is commonly used globally. It is associated with psychiatric problems, but the effects on the cardiovascular system are unclear. In this project, the investigators plan to study the effects of cannabis on the cardiovascular system. This will be done by using a non-invasive test to measure blood vessel function and by using blood samples to measure inflammation. As a control for this project, the investigators would like to test the blood vessel function and inflammation levels of participants who do not use cannabis. This study will provide important information on the long term cardiovascular effects of cannabis.
详细描述
Cannabis is the most commonly used illicit drug in the world, but the investigators do not know the long-term effects on the cardiovascular system in humans. The investigators have data from cell culture and small animal studies that cannabis is toxic to the cardiovascular system. Recently legalized in Canada, the long-term effects of cannabis use on the cardiovascular system may not be apparent for several decades. The purpose of this study is to test the effect of cannabis use on the vascular system. Using a non-invasive test of vascular function, the investigators would like to assess the effects of cannabis on chronic cannabis users. The investigators would also like to test if cannabis use by smoking and/or vaping causes adverse cardiovascular effects acutely. Lastly, the investigators would like to test blood from chronic cannabis users for inflammatory cytokines, which could further support our hypothesis that cannabis damages the cardiovascular system via inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age: 19 to 80
- •males and females
- •all ethnicities
- •cannabis use at least 3-4 times per week or more in the past 6 months (50 volunteers, experimental group)
- •patients who do not use cannabis (50 volunteers, control group)
- •no history of cardiovascular disease
排除标准
- •that ingest cannabis containing cannabidiol (CBD)
- •that are unable to provide a receipt for the cannabis product(s) they ingest
- •that are unwilling to stop consuming soy products and/or genistein 48 hours prior to appointments.
结局指标
主要结局
Inflammation
时间窗: Baseline measurement.
The investigators will measure the concentration of inflammatory cytokines using an Olink for chronic cannabis users and the control group.
Endothelial function
时间窗: Baseline measurement.
The investigators will measure the reactive hyperaemia index (RHI) using an EndPAT device for both groups.
次要结局
- BMI(Baseline measurement.)
- Blood pressure(Baseline measurement.)
- Cholesterol Level(Baseline measurement.)
研究者
Mark Chandy
Assistant Professor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's