NCT07281807
Not yet recruiting
Phase 4
Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars
RANA AHMAD0 sites60 target enrollmentStarted: January 1, 2026Last updated:
Interventionspiroxicam 20mg
Overview
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- RANA AHMAD
- Enrollment
- 60
- Primary Endpoint
- pain after single visit root canal treatment
Overview
Brief Summary
To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Care Provider)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy patient ranging between 18-40 years
- •Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs.
- •Teeth having mature apex confirmed by periapical radiographs.
Exclusion Criteria
- •History of systemic disorders including HIV, Hepatitis
- •Pregnancy (As per Medical record/ Verbally)
- •Patient using medication such as analgesics or anti-inflammatory drugs
- •Patient allergic to lignocaine, piroxicam and prednisolone
- •Tooth not suitable for restoration
- •Periodontal probing depth ≥ 4mm
- •Retreatment cases
- •Patients having calcified canals assessed by radiographic findings
Arms & Interventions
Group A: piroxicam
Experimental
Group A: patients will be given piroxicam 20mg as premedication
Intervention: piroxicam 20mg (Drug)
Outcomes
Primary Outcomes
pain after single visit root canal treatment
Time Frame: 48 hours
pain score on visual analogue scale
Secondary Outcomes
No secondary outcomes reported
Investigators
RANA AHMAD
Dr
Shaheed Zulfiqar Ali Bhutto Medical University
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