Evaluation of the predictive role of serial plasmaBNP measurement in assessing fluid status anddevelopment of Acute Kidney Injury in Criticallyill patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- Primary outcome will be evaluated in the form of development of AKI in critically ill patients
研究概览
简要总结
Brain natriuretic peptide (BNP) is a biomarker that can be easily obtained. It is a plasma neurohormone produced primarily by ventricular myocardiocytes in response to myocardial stretching and volume overload [25]. Recent studies have shown that BNP as a marker of fluid overload in incident haemodialysis patients [26]. On the other hand, few studies have correlated BNP levels with development of AKI and recovery from AKI in different set-ups [27-32].
Therefore, the hypothesis of this study is that the serial BNP level measurement could predict development of AKI and fluid status in critically ill patients and also it has the potential to be a convenient cost-effective marker to titrate fluid management to avoid overload and Acute kidney Injury in those patients.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •All patient admitted in the NTU with Age more than 18 years during the study period.
排除标准
- •1 Age less than 18 years 2 Patients with chronic heart disease based on chart reviews 3 with an abnormal echocardiogram on admission systolic dysfunction 4 acute coronary syndromes 5 acute pulmonary embolisms 6 status post cardiopulmonary resuscitation 7 cor pulmonale 8 Chronic kidney disease on Hemodialysis 9 Pregnancy.
结局指标
主要结局
Primary outcome will be evaluated in the form of development of AKI in critically ill patients
时间窗: Within 72 hrs of admission into Critical Care Unit
次要结局
- Secondary outcome will be evaluated in terms of mortality in the critically ill patients(Within 7days of admission into critical care unit)