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临床试验/NCT06223087
NCT06223087已完成不适用

Effects of Winter Swimming on Blood Morphological, Rheological, and Biochemical Indicators and Oxidative Stress in Males

University School of Physical Education, Krakow, Poland2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2021年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
30
试验地点
2
主要终点
blood sampling: haemoglobin mass

研究概览

简要总结

Exposure of the human body to cold water triggers numerous beneficial physiological changes. The study aimed to assess the impact of regular winter swimming on blood morphological, rheological, and biochemical indicators and activity of antioxidant enzymes in males. The study includes winter swimmers and a control group. Blood samples were taken twice - before the start (November) of the winter swimming season and after its end (March). The average duration of ice water baths was 3-5 minutes, with a minimum frequency of once a week. The water temperature during the swimming did not exceed 10°C, approaching 0°C during the winter period.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
25 Years 至 60 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Good health, practitioners of winter swimming
  • control group: never did winter swimming and had a sedentary lifestyle.

排除标准

  • medical contraindications to winter bathing

结局指标

主要结局

blood sampling: haemoglobin mass

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of: mean corpuscular haemoglobin (MCH) \[pg\],

blood sampling: Erythrocytes

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of mean corpuscular volume (MCV) \[fl\], red blood cell distribution width standard deviation (RDW-SD) \[fl\],

blood sampling: haemoglobin

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of: Haemoglobin \[g/dl\], mean corpuscular haemoglobin concentration (MCHC) \[g/dl\],

blood sampling: erythrocytes

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Measurement of: Erythrocytes \[mln/μl\],

blood sampling: haematocrit

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of: haematocrit \[%\], red blood cell distribution width coefficient of variation (RDW-CV) \[%\],

blood sampling: rheology part 1

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of red cell elongation index (EI) \[arbitrary unit: AU\], erythrocyte aggregation amplitude (AMP) \[AU\],

blood sampling: rheology part 2

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of: aggregation index (AI) \[%\],

blood sampling:rheology part 3

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of: half-time of total aggregation (t1/2) \[s\].

blood sampling: platelets and leukocytes

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Measurements of: Platelets \[thousands/μl\], Leukocytes \[thousands/μl\], Neutrophils \[thousands/μl\], Eosinophils \[thousands/μl\], Basophils \[thousands/μl\], Lymphocytes \[thousands/μl\], Monocytes \[thousands/μl\].

blood sampling: oxidative stress - superoxide dismutase

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Measurement of superoxide dismutase (SOD) \[U/ml\],

blood sampling: Testosterone

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of Testosterone concentration \[ng/dl\],

blood sampling: Cortisol

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of Cortisol concentration \[µg/dl\],

blood biochemistry: Creatine

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Determination of Creatinine concentration \[µmol/l\],

blood sampling: oxidative stress

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Measurement of catalase (CAT) \[nmol/min/ml\], and glutathione peroxidase (GPx) \[nmol/min/ml\].

blood biochemistry: Urea

时间窗: twice: before the start of cold swimming in November and 5 months later (March), after the end of winter swimming

Measurement of: Urea \[mmol/l\].

次要结局

未报告次要终点

研究者

发起方
University School of Physical Education, Krakow, Poland
申办方类型
Other
责任方
Principal Investigator
主要研究者

Aneta Teleglow

Head of Blood Physiology Laboratory

University School of Physical Education, Krakow, Poland

研究点 (2)

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