Innovative Strategies to Promote Biomedical HIV Prevention Uptake and Retention Among High-risk Adults at Drinking Venues in Kenya and Uganda
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9,375
- 试验地点
- 2
- 主要终点
- Biomedical HIV Prevention Uptake at 4 Weeks
研究概览
简要总结
This study will test innovative interventions to increase uptake and use of biomedical HIV prevention options by engaging women and men at drinking venues in rural Kenya and Uganda in care, while gaining insights into the facilitators, barriers, and cost-effectiveness of these approaches.
详细描述
[BACKGROUND] Alcohol use is a common risk factor for both HIV prevention uptake and retention in sub-Saharan Africa (SSA). Interventions that promote biomedical HIV prevention (PrEP and PEP) among persons with heavy alcohol use and their sexual partners are urgently needed. Alcohol-serving drinking venues play an important role as sites of HIV transmission in SSA and are ideal sites to engage women and men at increased risk of HIV in biomedical prevention services.
[OVERVIEW] The investigators have developed a mobilization strategy of integrating HIV testing within multi-disease screening to recruit >2,000 people from drinking venues in Kenya and Uganda. The investigators now need to determine whether multi-disease mobilization can promote uptake of HIV prevention for adults at drinking venues in the context of new biomedical prevention options.
The project will rigorously test innovative interventions in Kenya and Uganda to increase uptake of biomedical HIV prevention, and assess facilitators, barriers, and cost-effectiveness of these approaches.
Specific Aims:
- Compare the effectiveness of two mobilization strategies to increase uptake of biomedical HIV prevention among adults at drinking venues.
- Determine the cost-effectiveness of interventions that increase biomedical HIV prevention uptake among adults at high-risk for HIV who attend drinking venues.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant Inclusion Criteria:
- •adult (≥18 years)
- •patron or worker at a drinking venue within the study community
排除标准
- 未提供
研究组 & 干预措施
Aim 1: HIV-focused mobilization
Patrons and workers at drinking venues will be given a recruitment card for free HIV testing at the local clinic.
干预措施: HIV-focused mobilization (Behavioral)
Aim 1: Multi-disease-focused mobilization
Patrons and workers at drinking venues will be given a recruitment card for free multi-disease testing at the local clinic, including: diabetes, hypertension, HIV, malaria, TB, pregnancy.
干预措施: Multi-disease-focused mobilization (Behavioral)
结局指标
主要结局
Biomedical HIV Prevention Uptake at 4 Weeks
时间窗: Measured 4 weeks after clinic screening visit
The proportion of HIV-negative adults, receiving an Aim 1 mobilization card, who initiate PrEP or PEP after mobilization. This outcome will be measured by pill dispensing records and Ministry of Health (MoH) PrEP and PEP registry records. Mean was calculated as the average percentage across the clusters (groups of nearby alcohol-serving venues).
次要结局
- Biomedical HIV Prevention Uptake at 8 Weeks(Measured 8 weeks after clinic screening visit)
- Biomedical HIV Prevention Uptake at 12 Weeks(Measured 12 weeks after clinic screening visit)
- HIV Testing Uptake(Measured at clinic screening visit)
- Yield of Adults With Untreated HIV(Measured at clinic screening visit)
- Yield of Adults With Heavy Alcohol Use(Measured at clinic screening visit)
- Adults With Untreated HIV Who Initiate ART(Measured within one week of presenting for clinic-based screening with a recruitment card)