Contamination of Bacillus Species Sepsis.

Completed

• Conditions: Bacillus Cereus Infection
• Interventions: Diagnostic Test: Ways to prevent these infections.

• Registration Number: NCT03377530
• Lead Sponsor: Hôpital NOVO

Brief Summary

Bacillus species are ubiquitous gram-positive spore-forming organisms. They rarely cause disease in the immunocompetent and are more frequently isolated as a culture contaminant. However, Bacillus Species can cause severe systemic infections in immunocompromised patients including preterm infants.

The purpose of this study is to identify the risk factors of these infections.

Detailed Description

Non-anthrax Bacillus Species bacteria can be responsible for food poisoning and local infections. Rarely, they lead to severe infections like blood stream infections and meningitis especially in immunocompromised patients like preterm infants.

Bacillus Cereus is the most common members of the genus Bacillus. Only few reports studied these systemic infections in premature neonates. In order to identify the risk factors for severe Bacillus Species infections, we studied retrospectively eleven cases of these infections in our NICU and reviewed series and report cases in literature.

Study Timeline

• Study Start: 2008-01-01
• Primary Completion: 2016-08-31
• Study Completion: 2016-08-31
• Study First Submitted: 2017-12-14
• Study First Submitted QC: 2017-12-14
• Study First Posted: 2017-12-19
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-26
• Last Update Posted: 2019-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• cases of Bacillus Species sepsis
• cases of Bacillus species meningitis
• with significant change in clinical status
• Bacillus Species is the only organism isolated

Exclusion Criteria

• Bacillus Species isolated with other organisms and Bacillus Species without clinical change were considered to be contaminants

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Premature neonates infected with bacillus Species	Ways to prevent these infections.	The investigators studied retrospectively eleven cases of these infections in our NICU and reviewed series and report cases in literature.

Primary Outcome Measures

Name	Time	Method
Severe infection rate due to Bacillus Sp germ	Through study completion, an average of 1 year.	The purpose of this database is to mesure the pathogenicity of this germ based on the severe infection rate

Secondary Outcome Measures

Name	Time	Method
To collecte the incriminated modes of contamination.	Through study completion, an average of 1 year.	The purpose of this database is to describe the incriminated modes of contamination.